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Determining the Mechanisms of Loss of CAR T Cell Persistence

NCT05809284 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2024-05-23

No results posted yet for this study

Summary

A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.

Conditions

  • Acute Lymphoblastic Leukemia With Failed Remission
  • Acute Lymphoblastic Leukemia Not Having Achieved Remission
  • Acute Lymphoblastic Leukemia, Pediatric
  • Acute Lymphoblastic Leukemia, Adult
  • Acute Lymphoblastic Leukemia, in Relapse

Sponsors & Collaborators

  • University College, London

    lead OTHER

Principal Investigators

  • Persis Amrolia, BSc,MBBS,PhD · UCL Institute of Child Health

Eligibility

Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-18
Primary Completion
2025-12-01
Completion
2025-12-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05809284 on ClinicalTrials.gov