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Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases

NCT05807256 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-06-18

No results posted yet for this study

Summary

Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques (ARTs), because there is no influence on the disease itself if the disease activity at conception is stable. On the other hand, patients suffering from connective tissue diseases, primarily Systemic Lupus Erythematosus (SLE) and patients suffering from primary or SLE-related Anti-Phospholipid Antibody Syndrome (APS), deserve more targeted therapies both in the context of ARTs and in the ensuing pregnancy.

To evaluate the response to ARTs in patients with systemic rheumatological diseases, both in terms of reactivation of the underlying pathology and in terms of ARTs outcome.

Conditions

  • Rheumatic Diseases
  • Fertility Disorders
  • Pregnancy, High Risk
  • Pregnancy Complications
  • Immunologic Disease

Interventions

OTHER

collection and analysis of treatments and procedures already performed by normal clinical practice

The patients' anthropometric variables; laboratory test results; PMA techniques (types of fertilization/drugs used for stimulation) and the outcome of the eventual pregnancy (ongoing treatment during the pregnancy itself, development of maternal/fetal complications, such as hypertension, preeclmpsia, thrombotic events, renal failure, disease flare, neonatal outcome) and data on the type of ovarian stimulation drug treatment.

Sponsors & Collaborators

  • IRCCS San Raffaele

    lead OTHER

Principal Investigators

  • Patrizia Rovere Querini, PhD, MD · IRCCS Ospedale San Raffaele

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-04
Primary Completion
2025-10-30
Completion
2025-11-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05807256 on ClinicalTrials.gov