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Lung Cancer Multi-omics Digital Human Avatars for Integrating Precision Medicine Into Clinical Practice

NCT05802771 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2023-04-07

No results posted yet for this study

Summary

The goal of this multi-centric observational clinical trial is to to develop accurate predictive models for lung cancer patients, through the creation of Digital Human Avatars using various omics-based variables and integrating well-established clinical factors with "big data" and advanced imaging features

The main goals of LANTERN project are:

* To develop prevention models for early lung cancer diagnosis;
* To set up personalized predictive models for individual-specific treatments;

Lung cancer patients will be prospectively enrolled and main omics data (including radiomics and genomics) will be collected, reflecting the main omics domains associated with the lung cancer diagnosis and decision making pathway.

An exploratory analysis across all collected datasets will select a pool of potential biomarkers to create a multiple distinct multivariate models, trained though advanced machine learning (ML) and AI techniques sub-divided into specific areas of interest. Finally, the developed predictive models will be validated in order to test their robustness, transferability and generalizability, leading to the development of the Digital Human Avatar.

Conditions

  • Non Small Cell Lung Cancer

Interventions

PROCEDURE

surgical resection

surgical resection of the lung cancer

Sponsors & Collaborators

  • Technische Universität Dresden

    collaborator OTHER

  • University of Debrecen

    collaborator OTHER

  • Hospital de la Santa creu i Sant Pau - Barcelona

    collaborator OTHER

  • Koc University Hospital

    collaborator OTHER

  • Accademia del Paziente Esperto EUPATI, Rome, Italy

    collaborator UNKNOWN

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2025-10-01
Completion
2026-06-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05802771 on ClinicalTrials.gov