Multi-omics Study of Tongue Coating in Malignant Tumors of Digestive Tract

Summary

This is a prospective, multi-center, observational cohort study and seeks to enroll 20000 patients with one malignant tumor of digestive tract or healthy individual.

This study collected tongue coating samples non-invasively and analyzed the tongue coating metaproteomics, metagenomics and metabolomics profiles of patients with gastrointestinal malignancies.

The performance characteristics(sensitivity and specificity) of tongue coating morphology, metaproteomics, metagenomics and metabolomics tests for detection of gastrointestinal malignancies are evaluated in comparison to pathology.

Conditions

• Malignant Tumors of Digestive Tract

Interventions

DIAGNOSTIC_TEST

Tongue coating sample collection and multi-omics analysis

Tongue coating sample collection and multi-omics analysis for building a diagnostic model

Sponsors & Collaborators

• First Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Liaoning Cancer Hospital & Institute

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Fujian Cancer Hospital

  collaborator OTHER_GOV

• Sun Yat-sen University

  collaborator OTHER

• The Second Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Sichuan Cancer Hospital and Research Institute

  collaborator OTHER

• Zhejiang Provincial Tongde Hospital

  collaborator OTHER

• Yuhang District Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• The First People's Hospital of Yuhang District

  collaborator OTHER

• The First Affiliated Hospital of Anhui University of Chinese Medicine

  collaborator OTHER

• BGI-Shenzhen

  collaborator INDUSTRY

• Shangyu People's Hospital

  collaborator OTHER

• Xianju People's Hospital

  collaborator UNKNOWN

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Zhejiang Cancer Hospital

  lead OTHER

Principal Investigators

• Xiangdong Cheng, PhD. · Zhejiang Cancer Hospital

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-04-01

Primary Completion

2024-03-31

Completion

2025-03-31

Countries

• China

Study Locations