Clinical Study of UCB Combined With UC-MSCs in the Treatment of Bone Marrow Failure Disorders

Summary

The multicenter collaborative clinical study conducted a systematic clinical observation in the treatment of bone marrow failure diseases via UCB\&UC-MSCs , in order to observe its clinical efficacy and safety.

Conditions

• Bone Marrow Failure Disorders

Interventions

DRUG

Cyclosporine A

3-5 mg per kilogram per day.

BIOLOGICAL

Umbilical cord blood & Umbilical cord derived mesenchymal stem cells

Intravenous infusion of umbilical cord blood and umbilical cord derived mesenchymal stem cells (5-8×10\^7) at 1 week interval.

Sponsors & Collaborators

• Shandong Province Third hospital

  collaborator OTHER

• Dezhou People's Hospital

  collaborator OTHER

• Children's Hospital Affiliated to Shandong University

  collaborator UNKNOWN

• The Second Affiliated Hospital of Shandong First Medical University

  collaborator OTHER

• Tai'an Central Hospital

  collaborator UNKNOWN

• Linyi People's Hospital

  collaborator OTHER

• Rizhao People's Hospital

  collaborator OTHER

• Lanling People's Hospital

  collaborator UNKNOWN

• Jining First People's Hospital

  collaborator OTHER

• Jining Medical University

  collaborator OTHER

• Zibo Municipal Hospital

  collaborator OTHER

• Binzhou People's Hospital

  collaborator OTHER

• The Affiliated Hospital of Binzhou Medical College

  collaborator UNKNOWN

• Shengli Oilfield Hospital

  collaborator OTHER

• Weihai Municipal Hospital

  collaborator OTHER

• Weihai Central Hospital

  collaborator OTHER

• Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Gansu Provincial Hospital of Traditional Chinese Medicine (TCM)

  collaborator UNKNOWN

• Wuwei People's Hospital

  collaborator UNKNOWN

• Gansu Wuwei Tumor Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• Yuncheng Institute of Hematology

  collaborator UNKNOWN

• Kaifeng Central Hospital

  collaborator OTHER

• Zhengzhou Central Hospital

  collaborator OTHER

• Air Force Hospital of Western War Zone

  collaborator UNKNOWN

• The First People' s Hospital of Yunnan Province

  collaborator UNKNOWN

• Zigong No.1 Peoples Hospital

  collaborator OTHER

• The First People's Hospital of Jingzhou

  collaborator OTHER

• Jiangxi Province Children's Hospital

  collaborator OTHER

• Second Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Yantai Ludong Hospital (Shandong Provincial Hospital Group)

  collaborator UNKNOWN

• Shandong Qilu Stem Cells Engineering Co., Ltd.

  lead INDUSTRY

Principal Investigators

• zhe Yu, MD · Shandong Province Third hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-08-01

Primary Completion

2025-04-30

Completion

2026-04-30

Countries

• China

Study Locations