MedTrace Logo

Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis

NCT05759845 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2023-03-08

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the efficacy and safety of Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis in outddor migraine patients attending headache clinic. The main question it aims to answer is whether there is any difference between the efficacy of Topiramate, Amitriptyline monotherapy and combination therapy in migraine prophylaxis. Participants will take Topiramate, Amitriptyline Monotherapy and Combination Therapy and maintain a headache diary. Researchers will compare Topiramate, Amitriptyline Monotherapy and Combination Therapy groups to see if there is any differences in efficacy and safety.

Conditions

Interventions

DRUG

Topiramate 25Mg Tab

topiramate 25mg daily for 7 days followed by 25mg twice daily for 11 weeks

DRUG

Amitriptyline 25 Mg Oral Tablet

Amitriptyline 10 Mg Oral Tablet daily for 7 days followed by 25mg daily for 11 weeks

DRUG

topiramate 25mg plus amitriptyline 25mg

topiramate 25mg daily for 7 days followed by 25mg twice daily for 11 weeks with Amitriptyline 10 Mg Oral Tablet daily for 7 days followed by 25mg daily for 11 weeks

Sponsors & Collaborators

  • Dr. Reaz Mahmud

    lead OTHER

Principal Investigators

  • Kazi Gias Uddin Ahmed, FCPS, MD · Dhaka Medical College

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-22
Primary Completion
2023-02-28
Completion
2023-05-31

Countries

  • Bangladesh

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05759845 on ClinicalTrials.gov