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Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA

NCT05756088 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2025-11-06

No results posted yet for this study

Summary

The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following:

* Blockages in the small blood vessels of the heart.
* Whether small blockages can turn into more severe blockages in the future.

Participants will undergo blood draws once every 3 months in the first year of the study (4 blood draws total, taking 15 minutes each) and their medical records will be reviewed for 3 years after the date they are enrolled in the study.

Conditions

  • Cardiac Allograft Vasculopathy
  • Endothelial Dysfunction
  • Microvascular Coronary Artery Disease

Interventions

DIAGNOSTIC_TEST

Blood draw to measure the levels of dd-cf DNA

Blood draw to measure the levels of dd-cf DNA.

Sponsors & Collaborators

  • Yale Cardiovascular Research Group

    collaborator OTHER

  • Natera, Inc.

    collaborator INDUSTRY

  • Yale University

    lead OTHER

Principal Investigators

  • Lavanya Bellumkonda, MD · Yale University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-31
Primary Completion
2030-06-30
Completion
2030-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05756088 on ClinicalTrials.gov