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The Effect Of Nebulizied Nitroglycerin As An Adjuvant Therapy For Persistent Pulmonary Hypertension Of Newborns

NCT05741229 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-06-29

No results posted yet for this study

Summary

This aim of the study is to evaluate the effect of nebulized nitroglycerin on echocardiographic (biventricular function, pulmonary artery pressure, PDA and PFO shunting and tissue doppler imaging) and clinical parameters (Oxygen saturation index, heart rate, blood pressure, mean airway pressure, ventilation setting) in patients with PPHN.

Conditions

  • Persistent Pulmonary Hypertension of the Newborn
  • Echocardiography
  • Respiratory Disease

Interventions

DRUG

Nebulized nitroglycerine as adjunctive therapy

Patients with PPHN will have nebulized nitroglycerine as adjunctive therapy

DRUG

conventional therapy for PPHN

patients will receive sildenafil which is used routinely in management of PPHN in our unit, in addition to appropriate oxygenation and ventilation.

Sponsors & Collaborators

  • Alexandria University

    lead OTHER

Principal Investigators

  • Hesham Ghazal, PhD · Alexandria University

  • Aly Mohamed Abdel-Mohsen, PhD · Alexandria University

  • Moataz Shawky Rezk, MD · Alexandria University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Hour
Max Age
7 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2024-12-30
Completion
2025-01-20

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05741229 on ClinicalTrials.gov