AHSCT Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Multiple Myeloma
NCT05740891 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 50
Last updated 2023-02-23
Summary
Clinical Study on the Safety and Effectiveness of Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Multiple Myeloma
Conditions
Interventions
- DRUG
-
BCMA CAR-T cells injection
Autologous hematopoietic stem cell transplantation combined with BCMA CAR-T cells
Sponsors & Collaborators
-
Yake Biotechnology Ltd.
collaborator INDUSTRY -
Zhejiang University
lead OTHER
Principal Investigators
-
He Huang, MD · First Affiliated Hospital of Zhejiang University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 30 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-03-31
- Primary Completion
- 2025-03-31
- Completion
- 2025-03-31
Countries
- China
Study Locations
More Related Trials
-
Safety and Efficacy of BCMA-Targeted CAR-T Therapy for Relapsed/Refractory Multiple Myeloma
NCT04272151 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
APRIL CAR-T Cell Therapy for Patients With BCMA/TACI Positive Relapsed and/or Refractory Multiple Myeloma
NCT04657861 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Study of CS1-targeted CAR-T Cells Therapy for Relapsed Multiple Myeloma After BCMA CAR-T Cells Therapy
NCT04541368 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Efficacy of Sequential BCMA CAR-T Cell Therapy Following Autologous Hematopoietic Stem Cell Transplantation in Transplant-eligible Newly Diagnosed Multiple Myeloma
NCT06913192 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT04295018 ·Status: UNKNOWN ·Phase: PHASE1
-
Phase II Clinical Study on the Safety and Efficacy of Combined CAR-T Therapy Following Autologous Stem Cell Transplantation in Multiple Myeloma
NCT07034755 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
CD7 CAR-T Bridging to alloHSCT for R/R CD7+Malignant Hematologic Diseases
NCT05827835 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of CAR-T Cells Targeting Both BCMA and GPRC5D in Treatment of Relapsed or Refractory Multiple Myeloma
NCT05325801 ·Status: UNKNOWN ·Phase: PHASE1
-
CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignancies
NCT04603872 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT03751293 ·Status: UNKNOWN ·Phase: PHASE1
-
Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refractory Multiple Myeloma
NCT07032129 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma
NCT06581640 ·Status: RECRUITING ·Phase: PHASE2
-
CAR-T Cell Therapy Combined With Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Refractory Multiple Myeloma
NCT06913179 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
CD79b CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin's Lymphoma
NCT04609241 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
CAR-T Re-treatment for Refractory/Relapsed Multiple Myeloma
NCT03672253 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety and Efficacy of Anti-BCMA/FcRL5 CAR-T Cell Therapy in Treating Relapsed and Refractory Multiple Myeloma (R/R MM)
NCT06759181 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Multi-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma
NCT04689659 ·Status: COMPLETED ·Phase: PHASE2
-
B Cell Maturation Antigen Targeted CAR-T Cells in Treatment With Relapsed and Refractory Multiple Myeloma
NCT05150522 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Study of CAR-BCMA T in Patients With Refractory or Relapsed Multiple Myeloma
NCT03716856 ·Status: UNKNOWN ·Phase: PHASE1
-
BCMA-Targeted CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease
NCT04271644 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
An Exploratory Clinical Study Evaluating the Safety and Efficacy of Anti CD30 CAR T Cells in Patients With CD30+ Relapsed/Refractory Lymphoma
NCT05208853 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma
NCT03758417 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of C-CAR088 in Patients With Relapsed or Refractory Multiple Myeloma
NCT05521802 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
NCT03815383 ·Status: UNKNOWN ·Phase: PHASE1
-
Humanized CAR-T Cells of Anti-BCAM and Anti-CD19 Against Relapsed and Refractory Multiple Myeloma
NCT04194931 ·Status: UNKNOWN ·Phase: PHASE1