Construction of Molecular Diagnostic Marker Model for Pancreatic Cystic Tumors Based on Pancreatic Cystic Fluid Samples

Summary

The goal of this observational study is to test in patients with cystic tumor of pancreas. The main questions it aims to answer are:

Screening of molecular diagnostic markers for pancreatic cystic tumors by cfDNA methylation sequencing of pancreatic cystic fluid and proteomic assays to distinguish benign from malignant and mucinous/non-mucinous, correlate with pathological features, and find molecular features associated with the degree of malignancy.

Participants will Provide post-operative cyst fluid specimens.

Conditions

• Pancreatic Neoplasms
• DNA Methylation
• Proteome

Interventions

DIAGNOSTIC_TEST

cfDNA methylation sequencing and proteome analysis

Sequencing of cfDNA methylation and proteomic analysis of two sets of capsular fluid samples

Sponsors & Collaborators

• Oriental Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University

  collaborator UNKNOWN

• Zhejiang University

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• LanZhou University

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  collaborator OTHER

• Peking University Cancer Hospital & Institute

  collaborator OTHER

• First Hospital of China Medical University

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

  collaborator OTHER

• The Second Affiliated Hospital of Baotou Medical College

  collaborator OTHER

• Shandong Province Third hospital

  collaborator OTHER

• Zhaoshen Li

  lead OTHER

Principal Investigators

• Shiyu Li · Changhai Hospital

• Chengye Pan · Changhai Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-03-01

Primary Completion

2025-07-31

Completion

2025-07-31

Countries

• China

Study Locations