Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation
NCT05737706 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 63
Last updated 2025-04-06
Summary
A Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation.
Conditions
- Solid Tumor
- Advanced Solid Tumor
- Non-small Cell Lung Cancer
- Colo-rectal Cancer
- Pancreatic Adenocarcinoma
Interventions
- DRUG
-
MRTX1133
KRAS G12D Inhibitor
Sponsors & Collaborators
-
Mirati Therapeutics Inc.
lead INDUSTRY
Principal Investigators
-
Bristol-Myers Squibb · Bristol-Myers Squibb
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-03-06
- Primary Completion
- 2025-03-10
- Completion
- 2025-03-10
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
NCT04383210 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of MRG002 in the Treatment of Patients With HER2-mutated Unresectable/Metastatic Non-small Cell Lung Cancer (NSCLC).
NCT05141786 ·Status: UNKNOWN ·Phase: PHASE2
-
Studying An Investigational Drug Crizotinib (PF-02341066) In Non Non-Small Cell Lung Cancer Tumors That Are Positive For Anaplastic Lymphoma Kinase (ALK)
NCT01121588 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
NCT06875310 ·Status: RECRUITING ·Phase: PHASE3
-
MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer
NCT04762199 ·Status: RECRUITING ·Phase: PHASE1
-
Phase 1/2 Study of BBT-176 in Advanced NSCLC With Progression After EGFR TKI Treatment
NCT04820023 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Aumolertinib With Chemotherapy or Alone Compared With Osimertinib in Patients With Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer
NCT05493501 ·Status: TERMINATED ·Phase: PHASE3
-
Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT02206763 ·Status: TERMINATED ·Phase: PHASE1
-
A Study to Evaluate the Efficacy and Safety of MRG003 in Patients With EGFR-Positive Advanced Non-Small Cell Lung Cancer
NCT04838548 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of AT13387 in Patients With Non-Small Cell Lung Cancer (NSCLC) Alone and in Combination With Crizotinib
NCT01712217 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Almonertinib Combined With Palbociclib in Patients With Advanced Solid Tumors Harboring KRAS Mutations
NCT06947811 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Investigate Safety, Tolerability, PK and Anti-tumor Activity of TRX-221 in EGFRm NSCLC Patients
NCT06186076 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Phase 1b/2 Clinical Study to Evaluate the Safety and Tolerability and Efficacy of AZD4547
NCT05086666 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1
NCT05276726 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
NCT07094204 ·Status: RECRUITING ·Phase: PHASE1
-
D-1553 Tablet Versus Docetaxel Injection for KRAS G12C Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer After Prior Standard Therapy Failure
NCT06300177 ·Status: RECRUITING ·Phase: PHASE3
-
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
NCT05315700 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Stereotactic Radiosurgery or Other Local Ablation Then Erlotinib in Epidermal Growth Factor Receptor (EGFR)
NCT01573702 ·Status: COMPLETED ·Phase: PHASE2
-
XZP-5809-TT1 Tablets in Patients With T790M Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT04622072 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of DBPR112 in Patients With Head and Neck Cancer and EGFR Mutated Lung Cancer
NCT03246854 ·Status: TERMINATED ·Phase: PHASE1
-
Long Term Safety Observation of Crizotinib in Chinese NSCLC Population
NCT03672643 ·Status: TERMINATED ·Phase: PHASE4
-
Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive
NCT07063329 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
NCT01392235 ·Status: COMPLETED ·Phase: PHASE2
-
First-line Treatment for Adenocarcinoma Patients With Epidermal Growth Factor Receptor (EGFR) Mutation
NCT00344773 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluate Safety and Tolerability of RX001 in Patients With KRAS Mutant Advanced NSCLC
NCT06934590 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1