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Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)

NCT05728645 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2022

Last updated 2025-04-01

No results posted yet for this study

Summary

Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia. Previous studies only focused on the hemodynamics after preoperative fluid infusion. Pre-operative fluid infusion can reduce the incidence of post-operative complications by preventing post-induction hypotension. The patients who is 18 years or older and undergo elective non-cardiac surgery with general anesthsia will be enrolled. The intervention is intravenous infusion of colloids or crytalloids before induction of general anesthesia. The primary outcome is the incidence of post-operative complications within 30 days.

Conditions

  • Postoperative Complications

Interventions

DRUG

Hydroxyethyl Starch 130/0.4 and Electrolyte injection of 5ml/kg

Intravenous Hydroxyethyl Starch 130/0.4 and Electrolyte injection of 5ml/kg before induction of general anesthesia

DRUG

Multiple Electrolytes injection of 5 ml/kg

Intravenous Multiple Electrolytes injection of 5ml/kg before induction of general anesthesia

Sponsors & Collaborators

  • Ningbo No.2 Hospital

    collaborator OTHER

  • The Affiliated Hospital Of Guizhou Medical University

    collaborator OTHER

  • First Affiliated Hospital of Chongqing Medical University

    collaborator OTHER

  • The Second Affiliated Hospital of Dalian Medical University

    collaborator OTHER

  • Yan'an University Affiliated Hospital

    collaborator OTHER

  • Shenzhen University General Hospital

    collaborator OTHER

  • Xijing Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-12
Primary Completion
2025-03-28
Completion
2025-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05728645 on ClinicalTrials.gov