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Hormonal Associations in Male Patients With Psoriasis Vulgaris

NCT05716152 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2023-02-08

No results posted yet for this study

Summary

A cross sectional clinical study will be conducted on male patients with moderate and sever psoriasis vulgaris to:

* Identify the pattern of serum testosterone level and tissue androgen receptors.
* Evaluate the relationship between serum testosterone level, tissue androgen receptors and the severity of psoriasis vulgaris

Conditions

  • Psoriasis Vulgaris

Interventions

DIAGNOSTIC_TEST

Morning blood sample and skin punch biopsy of 4 mm diameter.

1. Morning blood sample (8:00-10:00 am) will be obtained for assessment of Total Testosterone (TT), Free Testosterone (fT), Luteinizing hormone (LH), Follicle stimulating hormone (FSH), and Estradiol (E2). 2. Skin biopsy: Skin punch biopsy of 4 mm diameter will be obtained from both psoriasis patients (from the lesional and non-lesional sites), and the control group (normal skin). Tissue specimens will be used for formation of Paraffin embedded blocks. Slides will be stained by routine Hematoxylin and Eosin stain. The expression of AR will be measured by immune and histochemical staining by the use of a mouse monoclonal antibody

Sponsors & Collaborators

  • Sohag University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2024-02-28
Completion
2024-08-01
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05716152 on ClinicalTrials.gov