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NIR Fluorescent Molecular Probe for the Identification of Breast Tissue

NCT05708144 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2024-01-02

No results posted yet for this study

Summary

Accurate evaluation of tumor boundaries in breast-conserving surgery is critical to reducing the second operation of patients. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, very effective probes can be applied to clinical trials up to now, which limits the clinical application of fluorescence imaging. Here we developed a new technology that can quickly identify the tumor area of the resected breast tissue during the operation and distinguish the tumor boundary. In brief, the breast tissues were incubated with the probe immediately after intraoperative resection and imaged to identify the tumor area and distinguish the tumor boundary. The accuracy of fluorescence imaging was confirmed by pathological diagnosis.

Conditions

Interventions

DIAGNOSTIC_TEST

ICG-SG incubation solution

The fresh excision breast cancer tissues were completely soaked in the incubation solution and performed fluorescence imaging.

Sponsors & Collaborators

  • Xiang'an Hospital of Xiamen University

    lead OTHER

Principal Investigators

  • Guojun Zhang, MD · Xiang'an Hospital of Xiamen University

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-17
Primary Completion
2023-10-30
Completion
2023-10-30

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05708144 on ClinicalTrials.gov