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Scrambler Therapy for Corticobasal Syndrome-Associated Pain

NCT05653778 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-01-13

No results posted yet for this study

Summary

The goal of this pilot trial is to test whether scrambler therapy (ST) is an effective treatment for neuropathic pain in patients with corticobasal syndrome (CBS).

The main question it aims to answer is:

Will ST reduce pain scores by at least 33% at one month in this pilot trial, justifying further multi-center trials?

Participants will:

* be randomly assigned treatment from either transcutaneous electrical nerve stimulation (TENS) or ST for pain initially (eventually all patients will receive ST).
* have superficial electrocardiogram (ECG) electrodes placed on the dermatomes involved with pain
* obtain treatment lasting 30-40 minutes or until pain relief is obtained

Researchers will compare patient's response to pain relief with TENS and ST to determine if ST is an effective treatment for central neuropathic pain.

Conditions

  • Corticobasal Degeneration
  • Corticobasal Syndrome
  • Pain, Neuropathic

Interventions

DEVICE

Scrambler therapy

Superficial electrocardiogram (ECG) electrodes are placed on the dermatomes involved with pain, above the area of pain itself. Each treatment lasts 30-40 minutes or until pain relief is obtained.

DEVICE

TENS treatment

Superficial electrocardiogram (ECG) electrodes are placed on the dermatomes involved with pain, above the area of pain itself. Each treatment lasts 30-40 minutes or until pain relief is obtained.

Sponsors & Collaborators

Principal Investigators

  • Alexander Pantelyat, MD · Department of Neurology, Johns Hopkins School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-05
Primary Completion
2027-02-28
Completion
2027-02-28
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05653778 on ClinicalTrials.gov