Camrelizumab Combined With Bevacizumab and HAIC in Patients With Metastatic Liver Cancer Who Failed Standard Therapy
NCT05643417 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 80
Last updated 2022-12-08
Summary
This is a single center, multi-cohort, phase I basket trial to evaluate the safety and efficacy of camrelizumab in combination with bevacizumab and HAIC for metastatic liver cancer after standard treatment failure
Conditions
- Metastatic Liver Cancer
Interventions
- DRUG
-
HAIC、Bevacizumab、Camrelizumab
HAIC: refer to genetic test results,D1 Bevacizumab:7.5mg/Kg, D2, Q3W Camrelizumab:200mg, D2, Q3W
Sponsors & Collaborators
-
Fudan University
lead OTHER
Principal Investigators
-
Lu Wang · Fudan University
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-12-31
- Primary Completion
- 2023-10-31
- Completion
- 2024-10-31
Countries
- China
Study Locations
More Related Trials
-
Camrelizumab, Apatinib Plus HAIC Versus Camrelizumab and Apatinib for HCC With Portal Vein Invasion: a Randomized Trial
NCT05198609 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
HAIC Combined With Cadonilimab and Bevacizumab as First-line Therapy in Unresectable Hepatocellular Carcinoma
NCT05821361 ·Status: UNKNOWN ·Phase: PHASE2
-
Different First-line Immunotherapy for Advancer Hepatocellular Carcinoma: A Prospective Observational Study on Efficacy and Immune Microenvironment
NCT07147101 ·Status: RECRUITING
-
Evaluation Effectiveness and Safety of (cTACE or DEB-TACE + FOLFOX Regimen HAIC) Combined With Camrelizumab and Apatinib Mesylas in the Treatment of Advanced Hepatocellular Carcinoma
NCT04479527 ·Status: UNKNOWN ·Phase: PHASE2
-
bTAE-HAIC Combined With System Therapy for Intermediate-advanced Huge HCC
NCT06061276 ·Status: RECRUITING ·Phase: NA
-
Camrelizumab in Patients With Unresectable Hepatocellular Carcinoma
NCT04947956 ·Status: UNKNOWN
-
Candonilimab Plus Bevacizumab for Patients With Advanced HCC Who Progressed on A+T
NCT05886257 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of Camrelizumab Combined Apatinib in Hepatocellular Carcinoma Previously Treated With Immune Checkpoint Inhibitors (ICIs).
NCT04826406 ·Status: UNKNOWN ·Phase: PHASE2
-
Camrelizumab Combined with Rivoceranib and Hepatic Arterial Infusion Chemotherapy (HAIC) As Conversion Therapy for Potentially Resectable Hepatocellular Carcinoma(HCC)
NCT06796803 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2/PHASE3
-
Hyperbaric Oxygen Therapy Combined Camrelizumab in Patients With Advanced/Metastatic Hepatocellular Carcinoma
NCT05031949 ·Status: RECRUITING ·Phase: PHASE1
-
Lenvatinib Plus Tislelizumab Versus Lenvatinib Alone in Hepatocellular Carcinoma Previously Treated With Anti-PD1/PD-L1 and Bevacizumab
NCT07047586 ·Status: RECRUITING ·Phase: PHASE2
-
Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer
NCT05168163 ·Status: RECRUITING ·Phase: PHASE2
-
HAIC Combined With Durvalumab, Tremelimumab and Bevacizumab as Conversion Therapy for Potentially Resectable Hepatocellular Carcinoma
NCT05864755 ·Status: RECRUITING ·Phase: PHASE2
-
PD-L1 Antibody + Bevacizumab With Hepatic Arterial Infusion Chemotherapy for Advanced HCC
NCT06742424 ·Status: RECRUITING ·Phase: PHASE2
-
Radomised Phase II Study of MTL-CEBPA Plus Sorafenib or Sorafenib Alone
NCT04710641 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) Versus Camrelizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation
NCT05367687 ·Status: COMPLETED ·Phase: PHASE2
-
Standard Treatments of Very-early Stage Hepatocellular Carcinoma
NCT02728193 ·Status: COMPLETED ·Phase: NA
-
A Phase 2 Study of Brivanib in Chinese Patients With Previously Treated Advanced HCC
NCT03516071 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model.
NCT06311916 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
PM8002 in Combination With Chemotherapy as First Line Therapy in Hepatocellular Carcinoma
NCT05864105 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
FOLFOX Combined With Durvalumab (MEDI4736), Bevacizumab, and Stereotactic Body Radiotherapy in Sequential Treatment of Potentially Resectable Locally Advanced Hepatocellular Carcinoma
NCT07012798 ·Status: RECRUITING ·Phase: PHASE2
-
Lenvatinib in Combination With Camrelizumab as First-Line Therapy in Patients With Advanced HCC
NCT04443309 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer
NCT05010681 ·Status: RECRUITING ·Phase: PHASE2
-
Infusional FOLFOX Plus Camrelizumab and Apatinib vs HAIC-FOLFOX Plus Camrelizumab and Apatinib for Advanced HCC
NCT06172205 ·Status: RECRUITING ·Phase: PHASE3
-
A Trial of Hepatic Arterial Infusion Combined With Apatinib and Camrelizumab Versus Apatinib and Camrelizumab for C-staged Hepatocellular Carcinoma in BCLC Classification
NCT05313282 ·Status: UNKNOWN ·Phase: PHASE3