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NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

NCT05635851 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2026-04-23

No results posted yet for this study

Summary

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Conditions

  • Spinal Cord Injuries
  • Autonomic Dysreflexia

Interventions

DRUG

Glyceryl Trinitrate Only Product in Oromucosal Dose Form

Glyceryl trinitrate will be administered via sublingual spray.

OTHER

Placebo sublingual spray

A placebo sublingual spray will be administered.

Sponsors & Collaborators

  • University of British Columbia

    collaborator OTHER

  • Simon Fraser University

    lead OTHER

Principal Investigators

  • Victoria Claydon, PhD · Simon Fraser University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-12-31
Primary Completion
2028-02-29
Completion
2028-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05635851 on ClinicalTrials.gov