Effect of Silymarin in Metastatic Colorectal Cancer Patients
NCT05631041 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 64
Last updated 2023-12-22
Summary
this work is aim to assess the antitumor effect of silymarin in patients with metastatic colorectal cancer receiving chemotherapy with or without target therapy (Bevacizumab).
Conditions
Interventions
- DRUG
-
Silymarin
participants in silymarin group will receive silymarin 140 mg once daily.
Sponsors & Collaborators
-
Tanta University
lead OTHER
Principal Investigators
-
shimaa yassin, pharmacist · Tanta University
-
Tarek Mostafa, professor · Tanta University
-
Sahar Elhaggar, professor · Tanta University
-
Mohammed Alam El-Din, professor · Tanta University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-12-31
- Primary Completion
- 2024-11-30
- Completion
- 2024-12-31
Countries
- Egypt
Study Locations
More Related Trials
-
Prospective Assessment of Symptoms and Quality of Life in Rectal Cancer Patients Receiving Chemo-Radiotherapy
NCT00414232 ·Status: COMPLETED
-
Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis
NCT03149978 ·Status: UNKNOWN
-
Chemotherapy Alone Versus Chemotherapy Plus Targeted Therapy as Adjuvant Therapy for Initially Unresectable Colorectal Cancer Liver Metastases
NCT06027775 ·Status: COMPLETED
-
Evaluation of Low-dose Irinotecan and Cyberknife® SBRT to Treat Colorectal Cancer With Limited Liver Metastasis
NCT01847495 ·Status: WITHDRAWN ·Phase: NA
-
Evaluating the Benefits of Personalized Traditional Chinese Medicine in Postoperative Treatment for Locally Advanced Colorectal Cancer
NCT06596343 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Evaluation of the Efficacy and Safety of Bevacizumab Combined With PD-1 Monoclonal Antibody in Preoperative Neoadjuvant Therapy for MSS Colorectal Cancer With Liver Metastases
NCT06124729 ·Status: NOT_YET_RECRUITING
-
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Resectable Colorectal Cancer
NCT02688023 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Treatment of Fruquintinib Combined With Concurrent Chemoradiotherapy for LARC
NCT05575635 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence
NCT06120127 ·Status: RECRUITING ·Phase: PHASE2
-
Chemotherapy With DNA Damaging Agents In Colorectal Cancer
NCT01456923 ·Status: COMPLETED ·Phase: PHASE1
-
Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety
NCT01465451 ·Status: UNKNOWN ·Phase: PHASE3
-
The Effect of Multimodal Treatment of Rectal Cancer on Circulating Tumor Cells: A Prospective, Observational Study
NCT07112937 ·Status: RECRUITING
-
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for Locally Advanced Mid-low Rectal Cancer
NCT06024356 ·Status: UNKNOWN
-
Potential Predictive Biomarkers in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer
NCT03532711 ·Status: COMPLETED
-
Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer
NCT05414461 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Target Therapy on Patients Undergoing Synchronic Hepatectomy for Colorectal Liver Metastases
NCT01677728 ·Status: UNKNOWN
-
Clinical Effect of Neoadjuvant Hierarchical Treatment Based on Chemotherapy
NCT03071198 ·Status: UNKNOWN ·Phase: NA
-
Comprehensive Therapy to Relieving the Risk of Recurrence and Metastasis for Colorectal Cancer
NCT00689364 ·Status: UNKNOWN
-
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer
NCT05148767 ·Status: RECRUITING ·Phase: PHASE4
-
Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection
NCT05720559 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The Value of ctDNA on Chemotherapy Efficacy for mCRC
NCT04555369 ·Status: UNKNOWN ·Phase: NA
-
Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer
NCT06210971 ·Status: RECRUITING ·Phase: PHASE2
-
Thalidomide Enhances Clinical Efficacy of Cetuximab Combined With Standard Chemotherapy for Left Colorectal Cancer
NCT06279351 ·Status: RECRUITING ·Phase: PHASE2
-
Validate the Dosimetric Parameters That Correlate With Acute Hematologic Toxicity (HT) in Patients With Rectal Cancer
NCT02630056 ·Status: UNKNOWN
-
Multimodal Deep Learning Signature for Evaluation of Response to Bevacizumab in Patient With Colorectal Cancer Liver Metastasis
NCT05354674 ·Status: NOT_YET_RECRUITING