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Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment

NCT05620264 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 392

Last updated 2023-10-13

No results posted yet for this study

Summary

As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis management. First aim of this study will be to evaluate the influence of TNF-alpha on Gram+ and Gram- bacteria causing keratitis. Second aim of this study will be to develop an algorithm, that should help to distinguish between different pathogens causing keratitis.

Conditions

  • Keratitis Bacterial
  • Keratitis Fungal

Interventions

DIAGNOSTIC_TEST

Tear Sample Probe

Samples will be collected by conjunctival lavage of the affected eye without topical anesthesia. Sterile normal saline will be infused at room temperature into the lower conjunctival sac by gently pulling down the lower eyelid and with a needle-free insulin syringe. After few seconds, the lavage fluid will be aspirated back into the same syringe without the syringe touching the conjunctiva.

Sponsors & Collaborators

  • Johannes Kepler University of Linz

    lead OTHER

Principal Investigators

  • Matthias Bolz, MD · JKU Linz

Eligibility

Min Age
18 Years
Max Age
119 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-21
Primary Completion
2024-04-30
Completion
2024-10-15

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05620264 on ClinicalTrials.gov