Herpes Virus Infections in Kidney Transplant Patients

Summary

Kidney transplant recipients are at increased risk of infections, including Varicella-zoster virus (VZV) infections. Vaccination against VZV is routinely offered to all kidney transplant recipients and candidates in Denmark. In this exploratory observational study, the VZV specific immune response in kidney transplant candidates and recipients will be characterized at different time points in relation to transplantation, vaccination and infections. More knowledge on the immune reaction to transplantation, VZV vaccination and VZV infections may provide improved strategies for prevention and treatment of VZV infections in kidney transplant candidates and recipients.

Conditions

• Kidney Transplant; Complications
• Varicella Zoster Virus Infection
• Vaccine-Preventable Diseases

Sponsors & Collaborators

• Technical University of Denmark

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Susanne Dam Nielsen, MD, DMSc

  lead OTHER

Principal Investigators

• Susanne D Nielsen, MD, DMSc · Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet

• Søren S Sørensen, MD, DMSc · Department of Nephrology, Copenhagen University Hospital - Rigshospitalet

• Claus Bistrup, MD, PhD · Department of Nephrology, Odense University Hospital

• Henrik Birn, MD, PhD, DMSc · Department of Nephrology, Aarhus University Hospital

• Sine R Hadrup, MSc, PhD · Department of Health Technology, Technical University of Denmark

• Annemette Hald, RN · Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet

• Sunil K Saini, MSc, PhD · Department of Health Technology, Technical University of Denmark

• Isik S Johansen, MD, DMSc · Department of Infectious Diseases, Odense University Hospital

• Helle Bruunsgaard, MD, PhD, DMSc · Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet

• Carsten S Larsen, MD, DMSc · Department of Infectious Diseases, Aarhus University Hospital

• Zitta B Harboe, MD, PhD · Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital - North Zealand

• Moisés A Suarez Zdunek, MD · Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet

• Sebastian R Hamm, BSc.med. · Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-01-01

Primary Completion

2026-02-01

Completion

2026-02-01

Countries

• Denmark

Study Locations