A Drug Interaction Study of Cyclosporine and LY3502970 in Healthy Participants
NCT05573230 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 32
Last updated 2023-02-14
Summary
The main purpose of this study is to determine the levels of study drug called LY3502970 in the blood stream when administered alone and in combination with cyclosporine in healthy participants. The study will also evaluate the safety and tolerability of LY3502970 in healthy participants. This study will last up to approximately 76 days for each participant.
Conditions
- Healthy
Interventions
- DRUG
-
Midazolam
Administered orally.
- DRUG
-
LY3502970
Administered orally.
- DRUG
-
Cyclosporine
Administered orally.
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · Eli Lilly and Company
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 21 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2022-10-17
- Primary Completion
- 2023-01-17
- Completion
- 2023-01-17
Countries
- Singapore
Study Locations
More Related Trials
-
A Study to Assess Any Potential Interaction Between Colesevelam and Ciclosporin in Healthy Volunteers
NCT00692250 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study With Pravastatin and Cyclosporine
NCT01497483 ·Status: COMPLETED ·Phase: PHASE1
-
An Interaction Study of LY3200882 in Healthy Participants
NCT03792139 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Study of Patients Who Undergo Cycloserine, a 2nd-line Antituberculosis Medicament
NCT01002170 ·Status: COMPLETED
-
A Drug Interaction Study of LY3871801 in Healthy Participants
NCT05602675 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study of Intravenous Administration of SyB V-1901 and Cyclosporine in Japanese Healthy Subjects
NCT04542252 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Assess Effect of Cyclosporine on the Blood Levels of Ticagrelor
NCT01504906 ·Status: COMPLETED ·Phase: PHASE1
-
Ciprofloxacin XR Drug Interaction Study With MMX® Mesalazine/Mesalamine
NCT01402947 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants
NCT06503679 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
NCT06704763 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug-Drug Interaction Study to Assess the Pharmacokinetics of DC-806 When Orally Administered Alone, When Coadministered With Itraconazole, and When Coadministered With Carbamazepine in Healthy Adult Participants
NCT05994807 ·Status: COMPLETED ·Phase: PHASE1
-
Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates
NCT06930872 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.
NCT06975605 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants
NCT05202145 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Characterize the Effect on the Pharmacokinetics of ASP1941 and Sitagliptin When Given Together to Healthy Subjects
NCT01104532 ·Status: COMPLETED ·Phase: PHASE1
-
CKD-506 Drug-Drug Interaction Study in Healthy Male Subjects
NCT05238948 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants
NCT06111521 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
NCT02940379 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate
NCT02010970 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
NCT05965570 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study Between EDP-938, Cyclosporine and Prednisone in Healthy Adult Subjects
NCT03750383 ·Status: COMPLETED ·Phase: PHASE1
-
Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects
NCT04606537 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug-Drug Interaction Study of CTL0901 and CTL0902 Compared to Coadministration in Healthy Adult Volunteers
NCT05009368 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Drug Interaction of ASP015K and Tacrolimus
NCT01190670 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-drug Interaction Study (CKD-501, Ketoconazole)
NCT01330563 ·Status: COMPLETED ·Phase: PHASE1