Otoferlin Gene-mediated Hearing Loss Natural History Study
NCT05572073 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150
Last updated 2026-03-04
Summary
This is a retrospective and prospective longitudinal study in participants with Otoferlin Gene-Mediated Hearing Loss.
Conditions
- Sensorineural Hearing Loss, Bilateral
Interventions
- OTHER
-
Natural History Study
Natural History Study
Sponsors & Collaborators
- collaborator INDUSTRY
-
Akouos, Inc.
lead INDUSTRY
Principal Investigators
-
Peter Marks, MD · Eli Lilly and Company
Eligibility
- Max Age
- 44 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-07-14
- Primary Completion
- 2029-02-28
- Completion
- 2029-02-28
Countries
- United States
- Australia
- Germany
- Spain
- Taiwan
- Turkey (Türkiye)
- United Kingdom
Study Locations
More Related Trials
-
Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)
NCT05776459 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
The Sentio System: Post-market Evaluation of Safety and Performance in Adolescents
NCT06844071 ·Status: RECRUITING
-
OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
NCT04129775 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Natural History of Autosomal Dominant Hearing Loss
NCT04501081 ·Status: RECRUITING
-
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss
NCT02345031 ·Status: COMPLETED ·Phase: PHASE2
-
An Investigator Initiated Study for OTOV101N+OTOV101C Injection
NCT05901480 ·Status: UNKNOWN ·Phase: NA
-
Evaluation of the CochSyn Test Prototype to Measure Cochlear Synaptopathy
NCT06114680 ·Status: TERMINATED ·Phase: NA
-
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts
NCT00023036 ·Status: COMPLETED
-
Audiovestibular Function in Infratentorial Superficial Siderosis
NCT04200664 ·Status: COMPLETED
-
Cochlear Implantation Among Adults and Older Children With Unilateral or Asymmetric Hearing Loss
NCT02105441 ·Status: COMPLETED
-
Cochlear Implantation in Adults With Asymmetric Hearing Loss Clinical Trial
NCT03052920 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the CochSyn Device in Clinical Practice
NCT07091071 ·Status: COMPLETED ·Phase: NA
-
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations
NCT05788536 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss
NCT01518920 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of the Presence of SENS-401 in the Perilymph
NCT05258773 ·Status: COMPLETED ·Phase: PHASE2
-
A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations
NCT06019481 ·Status: WITHDRAWN
-
Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss
NCT06968507 ·Status: RECRUITING ·Phase: PHASE4
-
CI532 - Early Experience Study
NCT02755935 ·Status: COMPLETED ·Phase: NA
-
FX-322 in Adults With Stable Sensorineural Hearing Loss
NCT04120116 ·Status: COMPLETED ·Phase: PHASE2
-
Immunity After Cochlear Implantation and Perilymph Molecular Profiles in Sensorineural Hearing Loss
NCT05670158 ·Status: RECRUITING ·Phase: NA
-
Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss
NCT02132130 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Assessment of The Efficacy of Intratympanic Platelet Rich Plasma for Treatment of Sensorineural Hearing Loss.
NCT05786378 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness
NCT05318417 ·Status: RECRUITING ·Phase: NA
-
A Study of EH002 Gene Therapy for Otoferlin Gene Mutation-mediated Hearing Loss
NCT06722170 ·Status: RECRUITING ·Phase: NA
-
Open Label Study of OTO-104 in Subjects With Meniere's Disease
NCT02740387 ·Status: TERMINATED ·Phase: PHASE2