Trial Outcomes & Findings for Combining tDCS and CILT in Non-fluent Aphasia (NCT NCT05561400)

Combining tDCS and CILT in Non-fluent Aphasia

Picture Description using Main Concept Analysis (MCA), a reliable, valid method of discourse analysis. It captures a participant's ability to state the main points/highlights of a sequential story. Responses to the "Broken Window" picture sequence, a normed and standardized task are recorded as accurate and complete (3 points), accurate and incomplete (2 points), inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0points). The minimum score is 0 and the maximum score is 24. There are no subscales. The higher the score, the better the performance. Scores reported for individual participants are raw scores. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Picture Description using Main Concept Analysis (MCA), a reliable, valid method of discourse analysis. It captures a participant's ability to state the main points/highlights of a sequential story. Responses to the "Broken Window" picture sequence, a normed and standardized task are recorded as accurate and complete (3 points), accurate and incomplete (2 points), inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0points). The minimum score is 0 and the maximum score is 24. There are no subscales. The higher the score, the better the performance. Scores reported for individual participants are raw scores. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Picture Description using Main Concept Analysis (MCA), a reliable, valid method of discourse analysis. It captures a participant's ability to state the main points/highlights of a sequential story. Responses to the "Broken Window" picture sequence, a normed and standardized task are recorded as accurate and complete (3 points), accurate and incomplete (2 points), inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0points). The minimum score is 0 and the maximum score is 24. There are no subscales. The higher the score, the better the performance. Scores reported for individual participants are raw scores. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Picture Description using Main Concept Analysis (MCA), a reliable, valid method of discourse analysis. It captures a participant's ability to state the main points/highlights of a sequential story. Responses to the "Broken Window" picture sequence, a normed and standardized task are recorded as accurate and complete (3 points), accurate and incomplete (2 points), inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0points). The minimum score is 0 and the maximum score is 24. There are no subscales. The higher the score, the better the performance. Scores reported for individual participants are raw scores. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Story Retell using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful discourse. Responses to the "Cinderella" story retell task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 102. There are no subscales for this measure. Responses are scored using the following rubric: accurate and complete (3 points), accurate and incomplete (2 point), inaccurate and complete (2 point) inaccurate and incomplete (1 points) or absent (0 points). The higher the score, the better the performance. Participant scores are reported as raw scores. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Story Retell using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful discourse. Responses to the "Cinderella" story retell task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 102. There are no subscales for this measure. Responses are scored using the following rubric: accurate and complete (3 points), accurate and incomplete (2 point), inaccurate and complete (2 point) inaccurate and incomplete (1 points) or absent (0 points). The higher the score, the better the performance. Participant scores are reported as raw scores. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Story Retell using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful discourse. Responses to the "Cinderella" story retell task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 102. There are no subscales for this measure. Responses are scored using the following rubric: accurate and complete (3 points), accurate and incomplete (2 point), inaccurate and complete (2 point) inaccurate and incomplete (1 points) or absent (0 points). The higher the score, the better the performance. Participant scores are reported as raw scores. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Story Retell using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful discourse. Responses to the "Cinderella" story retell task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 102. There are no subscales for this measure. Responses are scored using the following rubric: accurate and complete (3 points), accurate and incomplete (2 point), inaccurate and complete (2 point) inaccurate and incomplete (1 points) or absent (0 points). The higher the score, the better the performance. Participant scores are reported as raw scores. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Procedural Discourse using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful procedural discourse. Responses "how to make a peanut butter sandwich" task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 30. There are no subscales. The higher the score, the better the performance. Participant responses are scored using a rubric: accurate and complete (3 points), accurate and incomplete (2 point)s, inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0 points). Participant scores are reported as raw scores. There are no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Procedural Discourse using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful procedural discourse. Responses "how to make a peanut butter sandwich" task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 30. There are no subscales. The higher the score, the better the performance. Participant responses are scored using a rubric: accurate and complete (3 points), accurate and incomplete (2 point)s, inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0 points). Participant scores are reported as raw scores. There are no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Procedural Discourse using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful procedural discourse. Responses "how to make a peanut butter sandwich" task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 30. There are no subscales. The higher the score, the better the performance. Participant responses are scored using a rubric: accurate and complete (3 points), accurate and incomplete (2 point)s, inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0 points). Participant scores are reported as raw scores. There are no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Procedural Discourse using Main Concept Analysis (MCA), counts of the number of main ideas or propositions that are necessary for successful procedural discourse. Responses "how to make a peanut butter sandwich" task, a normed and standardized task will be recorded using the standardized "counts" or "raw score" main concept analysis scoring system. The minimum score is 0 and the maximum score is 30. There are no subscales. The higher the score, the better the performance. Participant responses are scored using a rubric: accurate and complete (3 points), accurate and incomplete (2 point)s, inaccurate and complete (2 points), inaccurate and incomplete (1 point) or absent (0 points). Participant scores are reported as raw scores. There are no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many animals as they can in one minute. Norms for healthy adults is between 18-20 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17 items. The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many animals as they can in one minute. Norms for healthy adults is between 18-20 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17 items.The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many animals as they can in one minute. Norms for healthy adults is between 18-20 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17 items.The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many animals as they can in one minute. Norms for healthy adults is between 18-20 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17 items.The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many words they can that start with either /f/ in one minute. Norms for healthy adults is between 25-35 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17. The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many words they can that start with either /f/ in one minute. Norms for healthy adults is between 25-35 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17. The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many words they can that start with either /f/ in one minute. Norms for healthy adults is between 25-35 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17.The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Verbal Fluency is a normed and standardized task of working memory and word recall. Participant will name as many words they can that start with either /f/ in one minute. Norms for healthy adults is between 25-35 items listed within the one minute timeframe. The number of items listed is the participants raw score. The higher the score, the better the performance. A score considered "no concerns" is \>17. The minimum score is 0. There is no maximum score as this is a timed measure. There is no subscales for this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

To measure working memory, the participant will complete the 2 n-back test. The score represents the raw score which is calculated as the total possible minus errors, which is called the accuracy score. The higher the score the better. In healthy adults, the average accuracy score is between 50%-75%. A minium accuracy score is 0 and the maximum score is 100%. There are no subscales in this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

To measure working memory, the participant will complete the 2 n-back test. The score represents the raw score which is calculated as the total possible minus errors, which is called the accuracy score. The higher the score the better. In healthy adults, the average accuracy score is between 50%-75%.A minium accuracy score is 0 and the maximum score is 100%. There are no subscales in this measure. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

To measure working memory, the participant will complete the 2 n-back test. The score represents the raw score which is calculated as the total possible minus errors, which is called the accuracy score. The higher the score the better. In healthy adults, the average accuracy score is between 50%-75%. A minium accuracy score is 0 and the maximum score is 100%. There are no subscales in this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

To measure working memory, the participant will complete the 2 n-back test. The score represents the raw score which is calculated as the total possible minus errors, which is called the accuracy score. The higher the score the better. In healthy adults, the average accuracy score is between 50%-75%. A minium accuracy score is 0 and the maximum score is 100%. There are no subscales in this measure. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Stroke Aphasia Quality of Life (SA-QOL) is a participant perception survey. Response scale between 1 and 5. 1=Total help / couldn't do it at all / strongly agree, 2=a lot of help / a lot of trouble / moderately agree, 3= some help / some trouble / neight agree nor disagree, 4= a little help / a little trouble / moderately disagree or 5= no help needed / no trouble at all / strongly disagree. 3 subscales: Physical, the total number of questions is 16, minimum score is 16 and the maximum score is 80. Communication, the total number of qustions is 7, minimum score is 7 and maximum score is 35 Psychosocial, the total number of questions is 16, minimum score is 16 and maximum score is 80 Scores from these subscales are totalled and divided by 39 to get the score. Total minimum score is 1 and total maximum score is 5 Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Stroke Aphasia Quality of Life (SA-QOL) is a participant perception survey. Scale is between 1 and 5. 1=Total help / couldn't do it at all / strongly agree, 2=a lot of help / a lot of trouble / moderately agree, 3= some help / some trouble / neight agree nor disagree, 4= a little help / a little trouble / moderately disagree or 5= no help needed / no trouble at all / strongly disagree. 3 subscales: Physical, total number of questions is 16, minimum score is 16 and the maximum score is 80. Communication, total number of qustions is 7, minimum score is 7 and maximum score is 35 Psychosocial, the total number of questions is 16, minimum score is 16 and maximum score is 80 Scores from these subscales are totalled and divided by 39 to get the score. Total minimum score is 1 and total maximum score is 5. The higher the score reflect better quality of life. Baseline 1 and Follow up 1 refer to the first intervention condition in the cross over sequence.

Stroke Aphasia Quality of Life (SA-QOL) is a participant perception survey. Response scale is between 1 and 5. 1=Total help / couldn't do it at all / strongly agree, 2=a lot of help / a lot of trouble / moderately agree, 3= some help / some trouble / neight agree nor disagree, 4= a little help / a little trouble / moderately disagree or 5= no help needed / no trouble at all / strongly disagree. There are 3 subscales: Physical, total number of questions is 16, minimum score is 16 and the maximum score is 80. Communication, the total number of qustions is 7, minimum score is 7 and maximum score is 35 Psychosocial, the total number of questions is 16, minimum score is 16 and maximum score is 80 Scores from these subscales are totalled and divided by 39 to get the score. Total minimum score is 1 and total maximum score is 5. The higher the score reflect better quality of life. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.

Stroke Aphasia Quality of Life (SA-QOL) is a participant perception survey. Response scale is between 1 and 5. 1=Total help / couldn't do it at all / strongly agree, 2=a lot of help / a lot of trouble / moderately agree, 3= some help / some trouble / neight agree nor disagree, 4= a little help / a little trouble / moderately disagree or 5= no help needed / no trouble at all / strongly disagree. There are 3 subscales: Physical, the total number of questions is 16, minimum score is 16 and the maximum score is 80. Communication, the total number of qustions is 7, minimum score is 7 and maximum score is 35 Psychosocial, the total number of questions is 16, minimum score is 16 and maximum score is 80 Scores from these subscales are totalled and divided by 39 to get the score. Total minimum score is 1 and total maximum score is 5. The higher the score reflect better quality of life. Baseline 2 and Follow up 2 reflect the second intervention in the cross over sequence.