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A Novel Method for Treating Lung Met w/Combo of Electric Fields & Rad Therapy: A Single-Arm

NCT05555342 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2025-05-14

No results posted yet for this study

Summary

This is a phase 0, pilot prospective study to determine the feasibility of combined irreversible electroporation (IRE) and radiation therapy in subjects with lung tumors with metastatic cancer of any histology. These are subjects who have advanced disease (stage IV) or previously treated disease that has become progressive, recurrent, or metastatic.

Conditions

Interventions

PROCEDURE

Irreversible electroporation (IRE) ablation

IRE will be performed using the NanoKnife or Aliya System. CT or cone-beam CT will be used to direct electrode placement.

RADIATION

Radiation Therapy

Moderate-dose radiation therapy to the target tumor(s) in 1 fraction.

Sponsors & Collaborators

  • University of California, Irvine

    lead OTHER

Principal Investigators

  • Jeremy Harris, MD · Chao Family Comprehensive Cancer Center

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-03
Primary Completion
2023-09-29
Completion
2024-10-27
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05555342 on ClinicalTrials.gov