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Clinicopathological MRI and CSF Correlates in Huntington's Disease.

NCT05534139 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2022-09-09

No results posted yet for this study

Summary

In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and neuroinflammation. The relationship between iron accumulation and neuroinflammation, and the clinical and genetic characteristics of HD will be investigated. This will provide an important basis for the evaluation of brain iron levels as an imaging biomarker for disease state in HD and their relationship with the salient pathomechanisms of the disease.

Conditions

  • Huntington Disease

Interventions

DIAGNOSTIC_TEST

7T MRI-scan

MRI-scanning of the brain using a 7T-MRI scanner

DIAGNOSTIC_TEST

CSF collection via lumbar puncture

CSF is collected by doing a lumbar puncture

DIAGNOSTIC_TEST

Blood withdrawal

Blood is collected by doing a blood withdrawal

DIAGNOSTIC_TEST

Clinical measures

UHDRS-Total motor score, UHDRS-short problem behaviour assessment, UHDRS-Cognitive assessments

Sponsors & Collaborators

  • Brighton & Sussex Medical School

    collaborator OTHER

  • University of Ulm

    collaborator OTHER

  • Leiden University Medical Center

    lead OTHER

Principal Investigators

  • Susanne de Bot, MD PhD · Neurology

Eligibility

Min Age
21 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-11
Primary Completion
2023-08-31
Completion
2024-08-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05534139 on ClinicalTrials.gov