Trial Outcomes & Findings for Community-based Brain Health Program to Address Dementia Risk (NCT NCT05529706)
NCT ID: NCT05529706
Last Updated: 2026-07-27
Results Overview
NPS (Net Promoter Score) is a whole number on a scale of -100 to +100, calculated by subtracting the percentage of Detractors from the percentage of Promoters. Promoters (score 9-10) are likely to exhibit value-creating behaviors, such as referring other potential program participants. Detractors (score 0-6) are less likely to do so. Passives (score 7-8) fall in between. Passives count toward the total number of respondents, which decreases the percentage of Promoters and Detractors and pushes the score toward 0. Higher score is better.
COMPLETED
NA
86 participants
At 12 weeks
2026-07-27
Participant Flow
12 participants did not meet study criteria and 3 participants withdrew consent before group assignment.
Participant milestones
| Measure |
Brain Health Program
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Overall Study
STARTED
|
71
|
|
Overall Study
COMPLETED
|
66
|
|
Overall Study
NOT COMPLETED
|
5
|
Reasons for withdrawal
| Measure |
Brain Health Program
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Overall Study
Withdrawal by Subject
|
3
|
|
Overall Study
Withdrawn by Investigator
|
2
|
Baseline Characteristics
Community-based Brain Health Program to Address Dementia Risk
Baseline characteristics by cohort
| Measure |
Brain Health Program
n=71 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Age, Continuous
|
74.5 years
STANDARD_DEVIATION 5.8 • n=9 Participants
|
|
Sex: Female, Male
Female
|
59 Participants
n=9 Participants
|
|
Sex: Female, Male
Male
|
12 Participants
n=9 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
17 Participants
n=9 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
53 Participants
n=9 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=9 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=9 Participants
|
|
Race (NIH/OMB)
Asian
|
17 Participants
n=9 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=9 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=9 Participants
|
|
Race (NIH/OMB)
White
|
41 Participants
n=9 Participants
|
|
Race (NIH/OMB)
More than one race
|
2 Participants
n=9 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
11 Participants
n=9 Participants
|
|
Years of Education
|
16 years
STANDARD_DEVIATION 3.5 • n=9 Participants
|
|
Cognitive Abilities Screening Instrument-Short (CASI-Short)
|
31.2 units on a scale
STANDARD_DEVIATION 2.1 • n=9 Participants
|
PRIMARY outcome
Timeframe: At 12 weeksPopulation: While 71 started the intervention, 3 withdrew consent and 2 were withdrawn by investigator during the intervention so a total of 66 participants completed the study.
NPS (Net Promoter Score) is a whole number on a scale of -100 to +100, calculated by subtracting the percentage of Detractors from the percentage of Promoters. Promoters (score 9-10) are likely to exhibit value-creating behaviors, such as referring other potential program participants. Detractors (score 0-6) are less likely to do so. Passives (score 7-8) fall in between. Passives count toward the total number of respondents, which decreases the percentage of Promoters and Detractors and pushes the score toward 0. Higher score is better.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Net Promoter Score
|
65 score on a scale
Interval 51.0 to 79.0
|
SECONDARY outcome
Timeframe: At 12 weeksOutcome measures
| Measure |
Brain Health Program
n=71 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Percentage of Participants Who Complete at 80% of Intended Program Sessions.
|
66 Participants
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the program was easy to comprehend. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Program Comprehension
|
6.5 score on a scale
Standard Deviation 0.64
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the program was relevant. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Relevancy of Program
|
6.2 score on a scale
Standard Deviation 0.77
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the program effectively raised awareness about brain health and how to manage it. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Program Awareness
|
7.0 score on a scale
Standard Deviation 0.71
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the work assigned in the program was reasonable. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Program Work Assignments
|
6.8 score on a scale
Standard Deviation 0.77
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the program helped to make a positive lifestyle change. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Positive Lifestyle Change Post-program
|
6.8 score on a scale
Standard Deviation 0.76
|
SECONDARY outcome
Timeframe: At 12 weeksOne of the post-program survey questions asked participants whether the program was satisfying. This was measured on a 7-point Likert scale, ranging from 1 ("totally disagree") to 7 ("totally agree"). Higher score means a better outcome.
Outcome measures
| Measure |
Brain Health Program
n=66 Participants
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Program Satisfaction
|
6.1 score on a scale
Standard Deviation 0.89
|
Adverse Events
Brain Health Program
Serious adverse events
Adverse event data not reported
Other adverse events
| Measure |
Brain Health Program
n=71 participants at risk
A multimodal educational and interactive diet, exercise and computerized cognitive exercise public health program.
Brain Health Program: The Brain Health Program employs 1-hour/week group-based training and education regarding modifiable Alzheimer's disease dementia risk factors delivered over a 12-week period. Participants will be assigned into a group of up to 20 participants, and participants will engage the Brain Health Program collaboratively, as administered by the program content leader (instructor), while also being monitored and supported by the tech leader (in accordance with the Diabetes Prevention Program model).
|
|---|---|
|
Musculoskeletal and connective tissue disorders
Fall
|
1.4%
1/71 • Number of events 1 • Adverse event data are collected throughout the study duration. Study participation is 12 weeks.
Adverse events are assessed at each assessment visit (at Baseline and Post-Intervention visits) and throughout the intervention period.
|
|
Eye disorders
Eye Strain
|
1.4%
1/71 • Number of events 1 • Adverse event data are collected throughout the study duration. Study participation is 12 weeks.
Adverse events are assessed at each assessment visit (at Baseline and Post-Intervention visits) and throughout the intervention period.
|
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place