MedTrace Logo

Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery

NCT05525195 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 932

Last updated 2023-07-27

No results posted yet for this study

Summary

Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery. Guidelines from the European Society of Anesthesiology and Intensive Care recommends fibrinogen substitution based on viscoelastic tests in adult cardiac surgery. Cardiopulmonary bypass results in a profound hemodilution and dilution of all coagulation factors. This is especially true in children where the priming volume of the cardiopulmonary bypass circuit is much higher compared to the patient's weight than in adults. Cardiopulmonary bypass generates high levels of tissue plasminogen activator resulting in a hyperfibrinolysis, further lowering fibrinogen levels.

The aim of this retrospective study is to explore a possible relationship between preoperative fibrinogen levels and perioperative blood loss, as well as transfusion requirements in children undergoing cardiac surgery.

Conditions

  • Cardiac Surgery
  • Congenital Heart Disease
  • Cardiopulmonary Bypass
  • Fibrinogenemia

Interventions

PROCEDURE

Congenital cardiac surgery

All children who underwent congenital cardiac surgery with cardiopulmonary bypass between 2008 and 2018

Sponsors & Collaborators

  • Brugmann University Hospital

    lead OTHER

Principal Investigators

  • Bernard Wenderickx, MSc · HUDERF

Eligibility

Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-17
Primary Completion
2023-01-25
Completion
2023-02-10

Countries

  • Belgium

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05525195 on ClinicalTrials.gov