A Study of Brepocitinib in Adults With Active Non-Infectious Non-Anterior Uveitis
NCT05523765 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 26
Last updated 2025-07-25
Summary
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with active intermediate, posterior, or pan non-infectious uveitis (NIU).
Conditions
- Non-infectious Intermediate Uveitis
- Non-infectious Posterior Uveitis
- Non-infectious Pan Uveitis
Interventions
- DRUG
-
Brepocitinib
Oral Brepocitinib
Sponsors & Collaborators
-
Priovant Therapeutics, Inc.
lead INDUSTRY
Principal Investigators
-
Brendan Johnson, PhD · SVP, Early Development
Study Design
- Allocation
- RANDOMIZED
- Purpose
- OTHER
- Masking
- TRIPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 74 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-11-14
- Primary Completion
- 2024-07-30
- Completion
- 2024-07-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Safety Study of Intravitreal PP-001 in Patients With Chronic, Non-Infectious Uveitis
NCT03634475 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis
NCT00615693 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
NCT01032915 ·Status: TERMINATED ·Phase: PHASE3
-
A Trial of the Efficacy and Safety of Izokibep in the Treatment of Non-anterior Uveitis
NCT04706741 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
NCT01090310 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease Uveitis
NCT02258867 ·Status: TERMINATED ·Phase: PHASE3
-
Safety and Efficacy of AIN457 in Noninfectious Uveitis
NCT00685399 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation and Treatment of Patients With Inflammatory Eye Diseases
NCT00006188 ·Status: COMPLETED
-
Efficacy and Safety of Adalimumab Plus Medium Dose Oral Glucocorticosteroid for Refractory Behçet's Uveitis
NCT05105347 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis
NCT01684345 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy, Safety and Costs of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis
NCT04798755 ·Status: UNKNOWN ·Phase: PHASE3
-
Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment
NCT01747538 ·Status: TERMINATED ·Phase: PHASE3
-
Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis
NCT01103024 ·Status: WITHDRAWN ·Phase: PHASE3
-
Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate
NCT01314417 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Efficacy and Safety of Adalimumab in Patients With Active Uveitis
NCT01138657 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis
NCT01327664 ·Status: WITHDRAWN ·Phase: PHASE3
-
Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis ,
NCT01526889 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Daclizumab/Denileukin Diftitox to Treat Uveitis
NCT00326508 ·Status: COMPLETED ·Phase: PHASE2
-
Tacrolimus Ophthalmic Solution for the Treatment of Non-infectious Anterior Uveitis
NCT07285070 ·Status: RECRUITING ·Phase: PHASE2
-
Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation
NCT00415506 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)
NCT03834753 ·Status: COMPLETED ·Phase: PHASE3
-
Phase 2 Study of MM-093 to Treat Patients With Uveitis
NCT00444743 ·Status: COMPLETED ·Phase: PHASE2
-
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye
NCT03711929 ·Status: TERMINATED ·Phase: PHASE3
-
Study of Risk Factors for Therapeutic Failure in Chronic Non-Infectious Uveitis After First-Line Immunosuppressive Therapy
NCT06821971 ·Status: ACTIVE_NOT_RECRUITING
-
Daclizumab Injections to Treat Non-Infectious Sight-Threatening Uveitis
NCT00043667 ·Status: COMPLETED ·Phase: PHASE2