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Establishment and Application of Endometrial 3D-organoid in Endometrial Injury Repair

NCT05521932 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2025-03-27

No results posted yet for this study

Summary

Normal endometrial repair occurs without scar formation; however, in some women, these normal repair mechanisms are aberrant, resulting in intrauterine adhesion (IUA) formation. Intrauterine adhesion (IUA) is one of the common causes of secondary infertility, accounting for approximately 8% of disease etiologies while the pathogenesis of IUA remains unclear. Organoids derived from IUA endometrium can be used as excellent models to study IUA due to genetically stable passage and the characteristics of simulating the microenvironment of the uterine cavity.

Conditions

  • Asherman Syndrome

Interventions

OTHER

endometrium collected

endometrium tissue collected following adhesiolysis surgery

Sponsors & Collaborators

  • Women's Hospital School Of Medicine Zhejiang University

    lead OTHER

Principal Investigators

  • Ruijin Wu, M.D. · Women's Hospital, College of Medicine Zhejiang University

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-20
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05521932 on ClinicalTrials.gov