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The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

NCT05514197 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 73

Last updated 2025-11-19

No results posted yet for this study

Summary

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

Conditions

  • Ascorbic Acid
  • Postoperative Pain

Interventions

DRUG

Ascorbic acid 100mg/kg, Maximus 10g

Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction

DRUG

Control Rx

Intravenous loading 100ml normal saline

Sponsors & Collaborators

  • Chimei Medical Center

    lead OTHER

Principal Investigators

  • Jen-Yin Chen · Department of Anesthesiology, Chimei Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-02
Primary Completion
2023-12-13
Completion
2024-01-11

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05514197 on ClinicalTrials.gov