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MRI Study of Subjects with ASD, Their Relatives and TD

NCT05470088 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2025-03-13

No results posted yet for this study

Summary

This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD.

In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD.

This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute

Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD

Secondary objectives include:

* the identification of familial heritability patterns of ASD
* correlate data obtained in brain imaging with genetic data
* assess specificity and statistical reproducibility of the obtained results

Conditions

Interventions

OTHER

Neuroimaging (MRI)

Multimodal magnetic resonance imaging

Sponsors & Collaborators

  • APHP

    collaborator OTHER

  • Institut Pasteur

    collaborator INDUSTRY

  • Commissariat A L'energie Atomique

    collaborator OTHER_GOV

  • Institut National de la Santé Et de la Recherche Médicale, France

    lead OTHER_GOV

Principal Investigators

  • Richard Delorme, M.D, Ph.D · APHP, France

  • Josselin Houenou, M.D, Ph.D · Institut National de la Santé Et de la Recherche Médicale, France

Eligibility

Min Age
24 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-13
Primary Completion
2037-03-13
Completion
2039-09-13

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05470088 on ClinicalTrials.gov