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Definition for Biliary Atresia Associated Cholangitis After Surgery

NCT05464303 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2022-07-19

No results posted yet for this study

Summary

Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis.

Based on the above reasons, we used the Delphi method，in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia.

Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.

Conditions

  • Biliary Atresia
  • Cholangitis

Interventions

DRUG

Intravenous Antibodies

Treatment is usually performed with sensitive third-generation cephalosporins, and medication is adjusted according to blood culture results

Sponsors & Collaborators

  • Nanjing Children's Hospital

    lead OTHER

Principal Investigators

  • Tang weibing, Dr · Nanjing Children's Hospital

Eligibility

Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-15
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05464303 on ClinicalTrials.gov