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Protein Kinase A in Prostate Cancer Tissue.

NCT05460312 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2023-01-26

No results posted yet for this study

Summary

Prostate cancer is the most common malignancy in men. documented risk factors of prostate cancer are age, ethnicity, various genomic mutations and family history of prostate cancer. The cellular mechanisms of malignant transformation are numerous and not completely understood. A possible mechanism is induction of an inflammation resulting in cellular atypia and pre-malignant changes in the affected tissue by inducing a pro-inflammatory response or changes in extra cellular matrix. Protein Kinase A (PKA) is a key stone enzyme in various intra-cellular processes. Various infections' inflammations and malignancies were proved to impact PKA activity. The research hypothesis is that prostate cancer tissue will show a unique profile of PKA activity, regulation and intracellular distribution.

Conditions

  • Prostate Neoplasm
  • Inflammation
  • Benign Hyperplasia of Prostate

Interventions

DIAGNOSTIC_TEST

prostate biopsy

trans rectal ultrasound guided biopsies of prostate . Biopsy smaples will be referred to staining and western blot analysis.

Sponsors & Collaborators

  • Ziv Hospital

    lead OTHER_GOV

Eligibility

Min Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2024-03-31
Completion
2024-05-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05460312 on ClinicalTrials.gov