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Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in Zambia

NCT05454852 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 771

Last updated 2026-01-08

No results posted yet for this study

Summary

With the advent of universal eligibility for HIV treatment ("treat all") and same-day and community-based antiretroviral therapy (ART) initiation, retention in care after a patient has started ART remains the main challenge to achieving optimal outcomes in HIV treatment programs. Consistently across both time and geography, the highest risk for loss from care is during a patient's first six months after ART initiation, with about quarter of all patients not retained by the end of month 6.

One of the reasons for the high attrition from care in this early retention period is that the model of care offered to most newly-initiating and re-initiating patients has barely evolved from its original outlines. Patients in their first six months on ART are generally not eligible for lower-intensity, patient-centered "differentiated service delivery" models that make remaining in care easier for experienced patients. Instead, most early patients must still make multiple clinic visits that include clinical consultations with providers, and most can receive only 1-2 month supplies of medications at a time.

This protocol is for the PREFER-Zambia study, an activity of the Retain6 project. Retain6 aims to develop new models of care for patients' first six months on ART. PREFER-Zambia will collect data on patients' characteristics, clinical and non-clinical needs, and preferences for different types of services during their first six months after initiating ART. The investigators will conduct an observational, prospective cohort survey of newly-initiated or re-initiated adult ART patients at a selected set of 12 healthcare facilities in Zambia. Results are expected to inform the design of better models of service delivery for the early treatment period.

Conditions

Interventions

OTHER

Survey

Interviewer-administered survey

OTHER

Focus group

Focus group for selected participants

Sponsors & Collaborators

  • University of the Witwatersrand, South Africa

    collaborator UNKNOWN

  • Clinton Health Access Initiative Inc.

    collaborator OTHER

  • Bill and Melinda Gates Foundation

    collaborator OTHER

  • Boston University

    lead OTHER

Principal Investigators

  • Sydney Rosen · Boston University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-15
Primary Completion
2024-05-31
Completion
2026-12-31

Countries

  • South Africa
  • Zambia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05454852 on ClinicalTrials.gov