CD7 CAR-T for Patients With r/r CD7+ Hematologic Malignancies
NCT05454241 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 14
Last updated 2025-03-13
Summary
This is a open-label, phase 2 study to evaluate the efficacy, safety and PK of CD7 chimeric antigen receptors treatment for patients with refractory/relapsed CD7 positive hematological malignancies.
Conditions
Interventions
- DRUG
-
Anti-CD7 CAR-T
Universal CAR-T cells targeting CD7
Sponsors & Collaborators
-
Institute of Hematology & Blood Diseases Hospital, China
lead OTHER
Principal Investigators
-
Ying Wang, Dr. · Hematology Hospital, Chinese Academy of Medical Sciences
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 3 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-09-07
- Primary Completion
- 2024-08-31
- Completion
- 2024-08-31
Countries
- China
Study Locations
More Related Trials
-
RD13-02 for Patients With r/r CD7+ T Cell Hematologic Malignancies
NCT05923541 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluate the Safety and Efficacy of CD33 CAR-T in Patients With R/R AML
NCT05473221 ·Status: UNKNOWN ·Phase: PHASE1
-
Chimeric Antigen Receptor T-Cell (CAR-T) Cells in Patients With R/R T-LBL
NCT05554575 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Trial for the Safety and Efficacy of Anti-CD7 CAR-T Cell Therapy for Patients With Relapsed or Refractory CD7 Positive Hematological Malignancy
NCT04599556 ·Status: RECRUITING ·Phase: PHASE1
-
CD7 CAR-T for Patients With r/r CD7+ T-ALL/T-LBL
NCT05716113 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Non-gene Edited Anti-CD7 CAR T Cells for Relapsed/Refractory T Cell Malignances
NCT04934774 ·Status: UNKNOWN ·Phase: PHASE1
-
CD7 CAR-T Combined With Autologous Hematopoietic Stem Cell Transplantation
NCT07117305 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study on the Safety and Efficacy of CD7-Targeted Chimeric Antigen Receptor (CAR) Gene-Modified T Cells for the Treatment of CD7-Positive Hematological Malignancies
NCT07345780 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
CD7 CAR-T Cells for Patients With R/R CD7+ NK/T Cell Lymphoma,T-lymphoblastic Lymphoma and Acute Lymphocytic Leukemia
NCT04004637 ·Status: UNKNOWN ·Phase: PHASE1
-
Multi-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma
NCT04689659 ·Status: COMPLETED ·Phase: PHASE2
-
CD5 CART for the Treatment of Relapsed and Refractory CD5 Hematological Tumors
NCT07234110 ·Status: RECRUITING ·Phase: NA
-
Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Malignancies
NCT06316427 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study of Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of Relapsed/Refractory Non-Hodgkin Lymphoma
NCT05420493 ·Status: RECRUITING ·Phase: PHASE1
-
Anti-CD5 CAR T Cells for Relapsed/Refractory T Cell Malignancies
NCT04594135 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Study of Anti-CD1a CAR-T in the Treatment of R/R Acute T-lymphoblastic Leukemia/Lymphoblastic Lymphoma
NCT05745181 ·Status: RECRUITING ·Phase: PHASE2
-
CD7-specific CAR-T Cell in the Treatment of CD7-positive Relapsed/Refractory Hematologic Tumors
NCT06720324 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors
NCT04702841 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
uCD7 CART for Relapsed or Refractory CD7 Positive Hematologic Malignancies
NCT07109518 ·Status: RECRUITING ·Phase: PHASE1
-
CD7 CAR-T Cell Therapy Targeting CD7-positive Relapsed/Refractory T Cell Lymphoma/Acute Leukemia
NCT07008872 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
CD7 CAR-T Cells in T-cell Lymphoma/Leukemia
NCT05620680 ·Status: RECRUITING ·Phase: NA
-
The Safety and Efficay Investigation of CAR-T Cell Therapy for Patients With Hematological Malignancies
NCT05618041 ·Status: RECRUITING ·Phase: NA
-
Safety and Efficacy of Sequential CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma
NCT05651100 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Anti-CD33 CAR-T Cells for the Treatment of Relapsed/Refractory CD33+ Acute Myeloid Leukemia
NCT05445765 ·Status: UNKNOWN ·Phase: PHASE1
-
CD7 CAR-T Bridging to alloHSCT for R/R CD7+Malignant Hematologic Diseases
NCT05827835 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CD20-CD19 Compound CAR (cCAR) T Cells for Patients With Relapsed /Refractory B Cell Malignancies
NCT04156178 ·Status: UNKNOWN ·Phase: EARLY_PHASE1