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The Role of Functional Magnetic Resonance Imaging in Preoperative Assessment of Primary Penile Carcinoma

NCT05447273 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-04-03

No results posted yet for this study

Summary

The proposed project is intended as a prospective study that includes 60 patients with newly diagnosed penile squamous cell carcinoma (SCC) referred to Oslo University Hospital (OUH), Radiumhospitalet, for surgery, primarily organ-sparing surgery (OSS).

OSS may improve not only quality of life, but also quality of sexual function. However, there is a potential for increased risk of local recurrence after OSS compared to the amputation of the penis. Appropriate preoperative staging, including multi-parametric magnetic resonance imaging (mpMRI), can substantially improve selection of patients and decrease the recurrence rate after surgery.

MpMRI without artificial erection is promising diagnostic tool that is poised to be all-in-one solution for staging and preoperative assessment of primary penile cancer, especially prior to OSS. The method is non-invasive and thus comfortable to perform for most of the patients. Novel MRI techniques are not incorporated into current clinical recommendations, and the potential of new, functional sequences has not been evaluated before. The accuracy of functional, non-erectile mpMRI for detecting and staging of primary penile cancer is not known. Thus, the main purpose of this study is to assess the diagnostic value of this method for preoperative assessment of penile cancer.

Conditions

  • Penile Cancer

Interventions

DIAGNOSTIC_TEST

Multi-parametric, functional magnetic resonance imaging (MRI)

Multi-parametric, functional magnetic resonance imaging (MRI) will be performed in all included patients prior to surgery.

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Marta D Switlyk, MD PhD · Oslo University Hospital

Eligibility

Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-15
Primary Completion
2025-06-30
Completion
2030-01-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05447273 on ClinicalTrials.gov