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Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain

NCT05446480 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2022-07-06

No results posted yet for this study

Summary

The aim of this initial investigational study is to compare the effect of desloratadine on the inflammatory responses to heat stress in firefighters exercising in their personal protective equipment.

Conditions

  • Heat Stress, Exertional
  • Inflammatory Response
  • Firefighter Personal Protective Equipment

Interventions

DRUG

Desloratadine

Oral ingestion 10mg pill 2 hours prior to heat strain trial. Second 10mg dose 24-hours later.

DRUG

Placebo

Oral ingestion 10mg inert pill 2 hours prior to heat strain trial. Second dose 24-hours later.

OTHER

No Intervention

No pill ingestion during the trial - to discern the presence of a placebo effect from baseline inflammatory response

Sponsors & Collaborators

  • University of Victoria

    lead OTHER

Principal Investigators

  • Lynneth Stuart-Hill, PhD · University of Victoria

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-31
Primary Completion
2023-08-31
Completion
2023-08-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05446480 on ClinicalTrials.gov