Lymphaticovenous Anastomosis as Treatment for Lymphedema

Summary

The primary aim of this study is to investigate and test whether the use of combined indocyanine green (ICG) lymphography and ultra high frequency ultrasonography can correctly identify lymphatic vessels and venoles in close proximity to each other, for identification prior to lymphovenous anastomosis (LVA) surgery.

Conditions

• Breast Cancer Lymphedema
• Secondary Lymphedema
• Iatrogenic Lymphedema
• Lymphedema
• Lymphedema of Upper Limb
• Lymphedema Arm
• Lymphedema, Breast Cancer
• Breast Neoplasm
• Neoplasms
• Breast Cancer
• Breast Diseases
• Lymphatic Diseases
• Skin Diseases
• Postoperative Complications
• Pathologic Processes
• Anastomose
• Surgery
• Surgical; Lymphedema, Postmastectomy
• Postmastectomy Lymphedema
• Postmastectomy Lymphedema Syndrome Left Upper Limb
• Postmastectomy Lymphedema Syndrome Right Upper Limb
• Postmastectomy Lymphedema Syndrome

Interventions

PROCEDURE

Lymphovenous anastomosis

Pre-operative planning prior to lymphovenous anastomosis using ICG lymphography and ultra high frequency ultrasound for mapping of applicable vessels. During surgery, mapped vessels are freely dissected and anastomosed.

Sponsors & Collaborators

• Danish Cancer Society

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Caroline Lilja, MD · Department of Plastic Surgery at Odense University Hospital

• Jens Ahm Sørensen, MD, Prof, PhD · Department of Plastic Surgery at Odense University Hospital

• Jørn Bo Thomsen, MD, Prof, PhD · Department of Plastic Surgery at Odense University Hospital

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-05-11

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• Denmark

Study Locations