Impact of a Personalized Multicomponent Exercise Program in Real Conditions Among Older Adults With HIV

Summary

Longitudinal prospective multicenter study with intervention and control groups and a two-year follow up. Participants will include 40 sedentary adults 50 years old or older with HIV infection and 20 sedentary adults 50 years old or older without HIV infection. Our main objective is to analyze the effects of a personalized multicomponent exercise program (strength, resistance, balance, and flexibility) (PMEP) on physical function, frailty, and quality of life among older adults with HIV. As secondary objectives, we are going to analyze the effects of a PMEP on body composition, muscle function biomarkers, immunological biomarkers, microbiome, and adherence to PMEP in real conditions under intense, moderate nonexistent monitoring.

Conditions

• Frailty
• Quality of Life
• Physical Inactivity
• Body Composition

Interventions

BEHAVIORAL

Personalized multicomponent exercise program (strength, resistance, balance, and flexibility) (PMEP)

Physical activity expert will design for each participant a personalized exercise program according to baseline situation and previous physical activity. Both will be measured prior to initiation of activity program. Each participant is free to perform physical activity program at his house, outdoor or in a gym as long as it fulfills the prespecified requirements. Exercise programs will be acquired a more personalized shape during the course of the study. In order to motivate participants, personal motivational messages will be sent each week through mail contact or using "WhatsApp" Social Media. Physical activity will be registered in an activity wristband delivered to each participant at baseline evaluation.

OTHER

Body composition

Analyze the effects of PMEP on body composition in each evaluation using an impedance threshold device

OTHER

Musculoskeletal and visceral Ultrasound

Quadriceps muscle ultrasound (US) of the rectus femoris measured in each evaluation in order to analyze the effects of PMEP Visceral fat will be analyzed in each visit

Sponsors & Collaborators

• Instituto de Salud Carlos III

  collaborator OTHER_GOV

• Hospital Universitario Ramon y Cajal

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

50 Years

Max Age

120 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-01-01

Primary Completion

2023-10-01

Completion

2023-12-31

Countries

• Spain

Study Locations