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rTMS for Military TBI-related Depression

NCT05426967 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 198

Last updated 2026-04-29

No results posted yet for this study

Summary

The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a history of concussion/mild traumatic brain injury (TBI).

Conditions

  • Depressive Symptoms
  • Mild Traumatic Brain Injury
  • Concussion

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

Active rTMS

DEVICE

Sham rTMS

Sham comparator to active rTMS

Sponsors & Collaborators

  • Uniformed Services University of the Health Sciences

    collaborator FED

  • Congressionally Directed Medical Research Programs

    collaborator FED

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

    lead OTHER

Principal Investigators

  • David L Brody, MD, PhD · Uniformed Services University of the Health Sciences

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-16
Primary Completion
2026-09-30
Completion
2026-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05426967 on ClinicalTrials.gov