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Fabry Exercise Intolerance Study

NCT05413876 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2023-08-24

No results posted yet for this study

Summary

Patients and healthy controls will undergo cardiopulmonary exercises and testing of the muscles strength to gain additional understanding of exercise intolerance as Fabry disease (FD) manifestation. An additional needle muscle biopsy may be performed. Tissue analysis from this biopsy will include evaluation of the lipidomics profile and mitochondrial function. Results of the tests and any potential exercise intolerance will be compared against healthy, age-, sex- and BMI-matched volunteers. The hypothesis is that patients with FD will have reduced exercise capacity due to changes in skeletal and cardiac muscle energy metabolism.

Conditions

Interventions

OTHER

Intermittent cardiopulmonary exercise test

Exercise test with step-change from rest to a relatively low constant workload.

OTHER

Incremental cardiopulmonary exercise test

Exercise test with incremental workload until maximal workload.

Sponsors & Collaborators

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-10
Primary Completion
2024-01-02
Completion
2024-01-02

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05413876 on ClinicalTrials.gov