Trial Outcomes & Findings for Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress (NCT NCT05413512)
NCT ID: NCT05413512
Last Updated: 2025-06-24
Results Overview
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
170 participants
Primary outcome timeframe
18 minutes (approximately 9 minutes for each task)
Results posted on
2025-06-24
Participant Flow
Recruited in Waco, Texas area
All participants engaged in the acute psychological stress task.
Participant milestones
| Measure |
Acute Psychological Stress
Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses.
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|---|---|
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Overall Study
STARTED
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170
|
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Overall Study
COMPLETED
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170
|
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Overall Study
NOT COMPLETED
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0
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Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Baseline characteristics by cohort
| Measure |
Acute Psychological Stress
n=170 Participants
Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses.
Acute psychological stress: Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses.
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|---|---|
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Age, Categorical
<=18 years
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0 Participants
n=99 Participants
|
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Age, Categorical
Between 18 and 65 years
|
170 Participants
n=99 Participants
|
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Age, Categorical
>=65 years
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0 Participants
n=99 Participants
|
|
Age, Continuous
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22.08 years
STANDARD_DEVIATION 2.93 • n=99 Participants
|
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Sex: Female, Male
Female
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87 Participants
n=99 Participants
|
|
Sex: Female, Male
Male
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83 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
38 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
132 Participants
n=99 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
3 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Asian
|
30 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Black or African American
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21 Participants
n=99 Participants
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|
Race (NIH/OMB)
White
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103 Participants
n=99 Participants
|
|
Race (NIH/OMB)
More than one race
|
13 Participants
n=99 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
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Region of Enrollment
United States
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170 Participants
n=99 Participants
|
PRIMARY outcome
Timeframe: 18 minutes (approximately 9 minutes for each task)Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
Outcome measures
| Measure |
Acute Psychological Stress Task
n=169 Participants
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
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|---|---|
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Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)
Stroop task
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0.265 mL/(kg·min)
Standard Deviation 0.452
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Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)
MSIT task
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0.287 mL/(kg·min)
Standard Deviation 0.431
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PRIMARY outcome
Timeframe: 18 minutes (approximately 9 minutes for each stress task)Population: Data loss for 3 participants due to equipment malfunction.
Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).
Outcome measures
| Measure |
Acute Psychological Stress Task
n=167 Participants
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
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|---|---|
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Heart Rate (Bpm) Measured by Electrocardiogram
Stroop task
|
4.926 beats per minute (bpm)
Standard Deviation 7.456
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Heart Rate (Bpm) Measured by Electrocardiogram
MSIT
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2.826 beats per minute (bpm)
Standard Deviation 6.317
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PRIMARY outcome
Timeframe: 18 minutes (approximately 9 minutes for each stress task).Population: Participants who have full data for both acute psychological stress tasks during fMRI scanning.
Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.
Outcome measures
| Measure |
Acute Psychological Stress Task
n=160 Participants
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
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|---|---|
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Neural Activity Measured by fMRI
L Cerebellum_Crus2 (MSIT)
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-0.26 BOLD signal (Incon - Con)
Standard Error 0.88
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Neural Activity Measured by fMRI
L Parietal_inf (stroop)
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0.71 BOLD signal (Incon - Con)
Standard Error 0.41
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Neural Activity Measured by fMRI
R Angular (stroop)
|
0.54 BOLD signal (Incon - Con)
Standard Error 0.35
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|
Neural Activity Measured by fMRI
R Supp_Motor_Area (stroop)
|
1 BOLD signal (Incon - Con)
Standard Error 0.65
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Neural Activity Measured by fMRI
L Frontal_Inf_Tri (stroop)
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0.85 BOLD signal (Incon - Con)
Standard Error 0.56
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Neural Activity Measured by fMRI
L Parietal_Inf2 (stroop)
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0.66 BOLD signal (Incon - Con)
Standard Error 0.45
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Neural Activity Measured by fMRI
R Insula (stroop)
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0.70 BOLD signal (Incon - Con)
Standard Error 0.50
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Neural Activity Measured by fMRI
R Frontal_Inf_Oper (stroop)
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0.76 BOLD signal (Incon - Con)
Standard Error 0.60
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Neural Activity Measured by fMRI
R Vermis (stroop)
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0.84 BOLD signal (Incon - Con)
Standard Error 0.68
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Neural Activity Measured by fMRI
R Thalamus (stroop)
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0.48 BOLD signal (Incon - Con)
Standard Error 0.40
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Neural Activity Measured by fMRI
L Precuneus2 (stroop)
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-0.55 BOLD signal (Incon - Con)
Standard Error 0.52
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Neural Activity Measured by fMRI
L ParaHippocampal2a (stroop)
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-0.47 BOLD signal (Incon - Con)
Standard Error 0.50
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Neural Activity Measured by fMRI
L Angular2 (stroop)
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-0.49 BOLD signal (Incon - Con)
Standard Error 0.54
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Neural Activity Measured by fMRI
L Frontal_Med_Orb2 (stroop)
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-1.38 BOLD signal (Incon - Con)
Standard Error 1.57
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Neural Activity Measured by fMRI
L Frontal_Sup2 (stroop)
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-0.55 BOLD signal (Incon - Con)
Standard Error 0.66
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Neural Activity Measured by fMRI
L ParaHippocampal2 (stroop)
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-0.47 BOLD signal (Incon - Con)
Standard Error 0.58
|
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Neural Activity Measured by fMRI
R ParaHippocampal2 (stroop)
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-0.35 BOLD signal (Incon - Con)
Standard Error 0.46
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Neural Activity Measured by fMRI
R Precentral2 (stroop)
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-0.20 BOLD signal (Incon - Con)
Standard Error 0.31
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Neural Activity Measured by fMRI
R Rolandic_Oper2 (stroop)
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-0.19 BOLD signal (Incon - Con)
Standard Error 0.33
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Neural Activity Measured by fMRI
R Angular2 (stroop)
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-0.23 BOLD signal (Incon - Con)
Standard Error 0.45
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Neural Activity Measured by fMRI
R Amygdala2 (stroop)
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-0.21 BOLD signal (Incon - Con)
Standard Error 0.43
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Neural Activity Measured by fMRI
R Frontial_Sup2 (stroop)
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-0.24 BOLD signal (Incon - Con)
Standard Error 0.54
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Neural Activity Measured by fMRI
R Cerebelum_Crus2 (stroop)
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-0.29 BOLD signal (Incon - Con)
Standard Error 0.91
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Neural Activity Measured by fMRI
L Parietal_Inf (MSIT)
|
0.50 BOLD signal (Incon - Con)
Standard Error 0.40
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Neural Activity Measured by fMRI
R Parietal_Inf (MSIT)
|
0.49 BOLD signal (Incon - Con)
Standard Error 0.43
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Neural Activity Measured by fMRI
R Angular (MSIT)
|
0.35 BOLD signal (Incon - Con)
Standard Error 0.31
|
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Neural Activity Measured by fMRI
L Supp_Motor_Area (MSIT)
|
0.49 BOLD signal (Incon - Con)
Standard Error 0.45
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Neural Activity Measured by fMRI
L Frontal_Inf_Oper (MSIT)
|
0.54 BOLD signal (Incon - Con)
Standard Error 0.52
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Neural Activity Measured by fMRI
R Calcarine (MSIT)
|
0.45 BOLD signal (Incon - Con)
Standard Error 0.48
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Neural Activity Measured by fMRI
R Frontal_Inf_Oper (MSIT)
|
0.49 BOLD signal (Incon - Con)
Standard Error 0.53
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Neural Activity Measured by fMRI
R Insula (MSIT)
|
0.49 BOLD signal (Incon - Con)
Standard Error 0.54
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Neural Activity Measured by fMRI
R Frontal_Mid (MSIT)
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0.31 BOLD signal (Incon - Con)
Standard Error 0.37
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Neural Activity Measured by fMRI
L Thalamus (MSIT)
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0.32 BOLD signal (Incon - Con)
Standard Error 0.39
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Neural Activity Measured by fMRI
L Frontal_Mid_Orb (MSIT)
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0.25 BOLD signal (Incon - Con)
Standard Error 0.53
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Neural Activity Measured by fMRI
L Cingulum_Mid2 (MSIT)
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-0.40 BOLD signal (Incon - Con)
Standard Error 0.41
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Neural Activity Measured by fMRI
L Angular2 (MSIT)
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-0.51 BOLD signal (Incon - Con)
Standard Error 0.62
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Neural Activity Measured by fMRI
L Frontal_Sup2 (MSIT)
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-0.43 BOLD signal (Incon - Con)
Standard Error 0.52
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Neural Activity Measured by fMRI
L Frontal_Med_Orb2 (MSIT)
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-1.06 BOLD signal (Incon - Con)
Standard Error 1.33
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Neural Activity Measured by fMRI
R Hippocampus2 (MSIT)
|
-0.24 BOLD signal (Incon - Con)
Standard Error 0.37
|
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Neural Activity Measured by fMRI
R Angular2 (MSIT)
|
-0.27 BOLD signal (Incon - Con)
Standard Error 0.46
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Neural Activity Measured by fMRI
R Insula2 (MSIT)
|
-0.21 BOLD signal (Incon - Con)
Standard Error 0.35
|
|
Neural Activity Measured by fMRI
R Temporal_Mid2 (MSIT)
|
-0.32 BOLD signal (Incon - Con)
Standard Error 0.63
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Neural Activity Measured by fMRI
R Cerebellum_Crus2 (MSIT)
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-0.42 BOLD signal (Incon - Con)
Standard Error 0.83
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Neural Activity Measured by fMRI
R Precentral2 (MSIT)
|
-0.10 BOLD signal (Incon - Con)
Standard Error 0.30
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Adverse Events
Acute Psychological Stress
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place