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Radiation Field, Dose and Fractionation Related to Mandibular Complications

NCT05412849 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2024-05-23

No results posted yet for this study

Summary

Radiotherapy is inhibiting the healing capacity of the mandibular bone. Late complications as bone exposure, fracture of the jaw, osteoradionecrosis might be a consequence of this vulnerability. A factor that could be involved in the development of complications is field of radiation. There are limited number of studies investigating this relation.

Retrospective analysis of a head and neck oncology register with prospectively included patients will be performed. Patients will be related to the University hospitals in Lund, Umea, Orebro, Stockholm. A thorough analysis of the medical journals in this group of patients will be performed. Included patients have been treated with combination of surgery and radiotherapy to treat malignancies in the head and neck region. At least 12 months follow up period is needed for inclusion.

The scientific aim is to investigate weather the field of radiation and fractionation is crucial for developing the formentioned complications.

Conditions

  • Head and Neck Neoplasms
  • Osteoradionecrosis
  • Radiotherapy; Complications

Interventions

RADIATION

Radiotherapy

Radiotherapy site, time perspective and dose

Sponsors & Collaborators

  • Lund University Hospital

    lead OTHER

Principal Investigators

  • Martin Bengtsson, PhD · Lund University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2025-01-31
Completion
2025-07-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05412849 on ClinicalTrials.gov