Trial Outcomes & Findings for Innovation Labs to Enhance Collaboration (NCT NCT05395286)

NCT ID: NCT05395286

Last Updated: 2026-04-27

Results Overview

Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) benefits scale includes 17 items that tap into perceived motivators/benefits of collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 17 items, for a benefits scale score ranging from 1-4, with higher scores indicating greater collaboration readiness.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

94 participants

Primary outcome timeframe

15 months

Results posted on

2026-04-27

Participant Flow

Each application was rated by 2-4 raters on a 1-4 scale for bringing diverse expertise to the Innovation Lab topic and fit for the Innovation Lab approach. Applicants with consistently poor scores (\~≤2) were excluded from RCT participation.

Participant milestones

Participant milestones
Measure
Innovation Lab Group
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
Randomized to NOT attend the Innovation Lab
Overall Study
STARTED
47
47
Overall Study
End-of-treatment
46
40
Overall Study
6-Month Follow-Up
44
37
Overall Study
12-Month Follow-Up
39
34
Overall Study
COMPLETED
39
34
Overall Study
NOT COMPLETED
8
13

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

One participant in the Innovation Lab group did not disclose their sex.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
Total
n=94 Participants
Total of all reporting groups
Age, Continuous
38.3 Years
STANDARD_DEVIATION 5.6 • n=47 Participants
37.7 Years
STANDARD_DEVIATION 6.2 • n=47 Participants
38.0 Years
STANDARD_DEVIATION 5.9 • n=94 Participants
Sex: Female, Male
Female
33 Participants
n=46 Participants • One participant in the Innovation Lab group did not disclose their sex.
36 Participants
n=47 Participants • One participant in the Innovation Lab group did not disclose their sex.
69 Participants
n=93 Participants • One participant in the Innovation Lab group did not disclose their sex.
Sex: Female, Male
Male
13 Participants
n=46 Participants • One participant in the Innovation Lab group did not disclose their sex.
11 Participants
n=47 Participants • One participant in the Innovation Lab group did not disclose their sex.
24 Participants
n=93 Participants • One participant in the Innovation Lab group did not disclose their sex.
Ethnicity (NIH/OMB)
Hispanic or Latino
3 Participants
n=47 Participants
3 Participants
n=47 Participants
6 Participants
n=94 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
43 Participants
n=47 Participants
44 Participants
n=47 Participants
87 Participants
n=94 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
1 Participants
n=47 Participants
0 Participants
n=47 Participants
1 Participants
n=94 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=47 Participants
0 Participants
n=47 Participants
0 Participants
n=94 Participants
Race (NIH/OMB)
Asian
5 Participants
n=47 Participants
6 Participants
n=47 Participants
11 Participants
n=94 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=47 Participants
0 Participants
n=47 Participants
0 Participants
n=94 Participants
Race (NIH/OMB)
Black or African American
1 Participants
n=47 Participants
1 Participants
n=47 Participants
2 Participants
n=94 Participants
Race (NIH/OMB)
White
37 Participants
n=47 Participants
38 Participants
n=47 Participants
75 Participants
n=94 Participants
Race (NIH/OMB)
More than one race
3 Participants
n=47 Participants
1 Participants
n=47 Participants
4 Participants
n=94 Participants
Race (NIH/OMB)
Unknown or Not Reported
1 Participants
n=47 Participants
1 Participants
n=47 Participants
2 Participants
n=94 Participants
Region of Enrollment
United States
47 participants
n=47 Participants
47 participants
n=47 Participants
94 participants
n=94 Participants

PRIMARY outcome

Timeframe: 15 months

Population: Differing number of participants responded at different assessment points.

Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) benefits scale includes 17 items that tap into perceived motivators/benefits of collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 17 items, for a benefits scale score ranging from 1-4, with higher scores indicating greater collaboration readiness.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
MATRICx Collaboration Benefits/Motivators Scale
6-Month Follow-Up (Month 9)
3.31 Score on a scale
Standard Error .06
3.25 Score on a scale
Standard Error .08
MATRICx Collaboration Benefits/Motivators Scale
Baseline (Month 0)
3.41 Score on a scale
Standard Error .06
3.48 Score on a scale
Standard Error .06
MATRICx Collaboration Benefits/Motivators Scale
End of Treatment (Month 3)
3.29 Score on a scale
Standard Error .06
3.31 Score on a scale
Standard Error .07
MATRICx Collaboration Benefits/Motivators Scale
12-Month Follow-Up (Month 15)
3.34 Score on a scale
Standard Error .07
3.27 Score on a scale
Standard Error .08

PRIMARY outcome

Timeframe: 15 months

Population: Differing number of participants responded at different assessment points.

Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) Threats Scale includes 31 barriers to -- or threats of -- collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 31 items, for a Barriers/Threats scale score ranging from 1-4, with lower scores indicating greater collaboration readiness.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
MATRICx Collaboration Barriers/Threats Scale
Baseline (Month 0)
1.47 Score on a scale
Standard Error .04
1.45 Score on a scale
Standard Error .04
MATRICx Collaboration Barriers/Threats Scale
End of Treatment (Month 3)
1.60 Score on a scale
Standard Error .04
1.60 Score on a scale
Standard Error .06
MATRICx Collaboration Barriers/Threats Scale
6-Month Follow-Up (Month 9)
1.60 Score on a scale
Standard Error .05
1.65 Score on a scale
Standard Error .06
MATRICx Collaboration Barriers/Threats Scale
12-Month Follow-Up (Month 15)
1.61 Score on a scale
Standard Error .06
1.58 Score on a scale
Standard Error .05

PRIMARY outcome

Timeframe: 15 months

Population: Differing number of participants responded at different assessment points.

Self-report: The Transdisciplinary Orientation scale (TDO; Misra, Stokols, \& Cheng, 2015) is a 12-item scale that measures values, attitudes, and beliefs, and conceptual skills and behaviors, that assesses the degree to which participants are oriented towards transdisciplinary collaboration. Items are rated on a five-point scale (1="Strongly Disagree," 5="Strongly Agree"). The total score is the mean of all 12 items, with a resulting 1-5 range, in which higher scores indicate greater transdisciplinary collaboration orientation.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
Transdisciplinary Orientation Scale
Baseline (Month 0)
4.4 Score on a scale
Standard Error .08
4.4 Score on a scale
Standard Error .07
Transdisciplinary Orientation Scale
End of Treatment (Month 3)
4.2 Score on a scale
Standard Error .08
4.1 Score on a scale
Standard Error .11
Transdisciplinary Orientation Scale
6-Month Follow-Up (Month 9)
4.3 Score on a scale
Standard Error .08
4.4 Score on a scale
Standard Error .08
Transdisciplinary Orientation Scale
12-month Follow-Up (Month 15)
4.2 Score on a scale
Standard Error .09
4.4 Score on a scale
Standard Error .08

PRIMARY outcome

Timeframe: 36 Months (18-monts pre- and post-treatment, after excluding articles published within +/-3 months of the Innovation Lab)

Objective number of collaborators from published articles on PubMed

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
Collaboration Network Size
Pre-Treatment
27.6 Unique Collaborators
Standard Error 4.1
26.7 Unique Collaborators
Standard Error 3.7
Collaboration Network Size
Post-Treatment
34.6 Unique Collaborators
Standard Error 5.3
30.1 Unique Collaborators
Standard Error 4.8

SECONDARY outcome

Timeframe: 21 months (9 months pre-treatment [obtained at baseline and EOT]; 12 months post-treatment [obtained at 6- and 12-month follow-up])

Self-Reported Number of Grants Submitted per Year. For the post-treatment period, the number of grants submitted at 6- and 12-M follow-up were summed. To make the pre-treatment period (which covered only 9 months) comparable to the post-treatment period, the number of grants at baseline and EOT were summed, divided by 9, and then multiplied by 12. Participants who did not report the number of grants submitted were coded as zero for the ITT analysis.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
Self-Reported Number of Grants Submitted Per Year
Post-Treatment
2.6 Grants per year
Standard Error .4
1.6 Grants per year
Standard Error .3
Self-Reported Number of Grants Submitted Per Year
Pre-Treatment
2.7 Grants per year
Standard Error .4
2.8 Grants per year
Standard Error .4

SECONDARY outcome

Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])

Population: Differing number of participants responded at different assessment points.

The Innovation Lab group was asked to rate the degree to which "The Lab met the goal of forming new transdisciplinary collaborations", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
Randomized to NOT attend the Innovation Lab
ILab Met Goal - New Collab
End of Treatment
4.3 Score on a scale
Standard Deviation 0.8
ILab Met Goal - New Collab
6-Month Follow-Up
3.7 Score on a scale
Standard Deviation 1.0
ILab Met Goal - New Collab
12-Month Follow-Up
2.9 Score on a scale
Standard Deviation 1.4

SECONDARY outcome

Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])

Population: Differing number of participants responded at different assessment points.

The Innovation Lab group was asked to rate the degree to which "The Lab met the goal of developing novel grant proposals", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
Randomized to NOT attend the Innovation Lab
ILab Met Goal - Novel Proposals
End of Treatment
3.7 Score on a scale
Standard Deviation 1.1
ILab Met Goal - Novel Proposals
6-Month Follow-Up
3.4 Score on a scale
Standard Deviation 1.1
ILab Met Goal - Novel Proposals
12-Month Follow-Up
2.6 Score on a scale
Standard Deviation 1.4

SECONDARY outcome

Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])

Population: Differing number of participants responded at different assessment points.

The Innovation Lab group was asked to rate the degree to which "I would recommend an Innovation Lab to a colleague", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
Randomized to NOT attend the Innovation Lab
ILab - Recommend
End of Treatment
4.4 Score on a scale
Standard Deviation 0.9
ILab - Recommend
6-Month Follow-Up
4.3 Score on a scale
Standard Deviation 0.9
ILab - Recommend
12-Month Follow-Up
3.8 Score on a scale
Standard Deviation 1.4

SECONDARY outcome

Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])

Population: Differing number of participants responded at different assessment points.

The Innovation Lab group was asked to rate the degree to which "My experience in the Innovation Lab will have a positive impact on my work at my home institution", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.

Outcome measures

Outcome measures
Measure
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
Control Group
Randomized to NOT attend the Innovation Lab
ILab - Positive Impact
End of Treatment
4.4 Score on a scale
Standard Deviation 0.8
ILab - Positive Impact
6-Month Follow-Up
4.1 Score on a scale
Standard Deviation 0.9
ILab - Positive Impact
12-Month Follow-Up
3.7 Score on a scale
Standard Deviation 1.4

Adverse Events

Innovation Lab Group

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Control Group

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Larry Hawk

University at Buffalo

Phone: 716-645-0192

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place