Trial Outcomes & Findings for Innovation Labs to Enhance Collaboration (NCT NCT05395286)
NCT ID: NCT05395286
Last Updated: 2026-04-27
Results Overview
Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) benefits scale includes 17 items that tap into perceived motivators/benefits of collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 17 items, for a benefits scale score ranging from 1-4, with higher scores indicating greater collaboration readiness.
COMPLETED
NA
94 participants
15 months
2026-04-27
Participant Flow
Each application was rated by 2-4 raters on a 1-4 scale for bringing diverse expertise to the Innovation Lab topic and fit for the Innovation Lab approach. Applicants with consistently poor scores (\~≤2) were excluded from RCT participation.
Participant milestones
| Measure |
Innovation Lab Group
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
Overall Study
STARTED
|
47
|
47
|
|
Overall Study
End-of-treatment
|
46
|
40
|
|
Overall Study
6-Month Follow-Up
|
44
|
37
|
|
Overall Study
12-Month Follow-Up
|
39
|
34
|
|
Overall Study
COMPLETED
|
39
|
34
|
|
Overall Study
NOT COMPLETED
|
8
|
13
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
One participant in the Innovation Lab group did not disclose their sex.
Baseline characteristics by cohort
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
Total
n=94 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
38.3 Years
STANDARD_DEVIATION 5.6 • n=47 Participants
|
37.7 Years
STANDARD_DEVIATION 6.2 • n=47 Participants
|
38.0 Years
STANDARD_DEVIATION 5.9 • n=94 Participants
|
|
Sex: Female, Male
Female
|
33 Participants
n=46 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
36 Participants
n=47 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
69 Participants
n=93 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
|
Sex: Female, Male
Male
|
13 Participants
n=46 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
11 Participants
n=47 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
24 Participants
n=93 Participants • One participant in the Innovation Lab group did not disclose their sex.
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
3 Participants
n=47 Participants
|
3 Participants
n=47 Participants
|
6 Participants
n=94 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
43 Participants
n=47 Participants
|
44 Participants
n=47 Participants
|
87 Participants
n=94 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=47 Participants
|
0 Participants
n=47 Participants
|
1 Participants
n=94 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=47 Participants
|
0 Participants
n=47 Participants
|
0 Participants
n=94 Participants
|
|
Race (NIH/OMB)
Asian
|
5 Participants
n=47 Participants
|
6 Participants
n=47 Participants
|
11 Participants
n=94 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=47 Participants
|
0 Participants
n=47 Participants
|
0 Participants
n=94 Participants
|
|
Race (NIH/OMB)
Black or African American
|
1 Participants
n=47 Participants
|
1 Participants
n=47 Participants
|
2 Participants
n=94 Participants
|
|
Race (NIH/OMB)
White
|
37 Participants
n=47 Participants
|
38 Participants
n=47 Participants
|
75 Participants
n=94 Participants
|
|
Race (NIH/OMB)
More than one race
|
3 Participants
n=47 Participants
|
1 Participants
n=47 Participants
|
4 Participants
n=94 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=47 Participants
|
1 Participants
n=47 Participants
|
2 Participants
n=94 Participants
|
|
Region of Enrollment
United States
|
47 participants
n=47 Participants
|
47 participants
n=47 Participants
|
94 participants
n=94 Participants
|
PRIMARY outcome
Timeframe: 15 monthsPopulation: Differing number of participants responded at different assessment points.
Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) benefits scale includes 17 items that tap into perceived motivators/benefits of collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 17 items, for a benefits scale score ranging from 1-4, with higher scores indicating greater collaboration readiness.
Outcome measures
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
MATRICx Collaboration Benefits/Motivators Scale
6-Month Follow-Up (Month 9)
|
3.31 Score on a scale
Standard Error .06
|
3.25 Score on a scale
Standard Error .08
|
|
MATRICx Collaboration Benefits/Motivators Scale
Baseline (Month 0)
|
3.41 Score on a scale
Standard Error .06
|
3.48 Score on a scale
Standard Error .06
|
|
MATRICx Collaboration Benefits/Motivators Scale
End of Treatment (Month 3)
|
3.29 Score on a scale
Standard Error .06
|
3.31 Score on a scale
Standard Error .07
|
|
MATRICx Collaboration Benefits/Motivators Scale
12-Month Follow-Up (Month 15)
|
3.34 Score on a scale
Standard Error .07
|
3.27 Score on a scale
Standard Error .08
|
PRIMARY outcome
Timeframe: 15 monthsPopulation: Differing number of participants responded at different assessment points.
Self-report: The Motivation Assessment for Team Readiness, Integration, and Collaboration (MATRICx; Mallinson, Lotrecchiano, et al., 2016) Threats Scale includes 31 barriers to -- or threats of -- collaboration. Each is rated on a 1-4 scale. Scale scores were computed as the mean of all 31 items, for a Barriers/Threats scale score ranging from 1-4, with lower scores indicating greater collaboration readiness.
Outcome measures
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
MATRICx Collaboration Barriers/Threats Scale
Baseline (Month 0)
|
1.47 Score on a scale
Standard Error .04
|
1.45 Score on a scale
Standard Error .04
|
|
MATRICx Collaboration Barriers/Threats Scale
End of Treatment (Month 3)
|
1.60 Score on a scale
Standard Error .04
|
1.60 Score on a scale
Standard Error .06
|
|
MATRICx Collaboration Barriers/Threats Scale
6-Month Follow-Up (Month 9)
|
1.60 Score on a scale
Standard Error .05
|
1.65 Score on a scale
Standard Error .06
|
|
MATRICx Collaboration Barriers/Threats Scale
12-Month Follow-Up (Month 15)
|
1.61 Score on a scale
Standard Error .06
|
1.58 Score on a scale
Standard Error .05
|
PRIMARY outcome
Timeframe: 15 monthsPopulation: Differing number of participants responded at different assessment points.
Self-report: The Transdisciplinary Orientation scale (TDO; Misra, Stokols, \& Cheng, 2015) is a 12-item scale that measures values, attitudes, and beliefs, and conceptual skills and behaviors, that assesses the degree to which participants are oriented towards transdisciplinary collaboration. Items are rated on a five-point scale (1="Strongly Disagree," 5="Strongly Agree"). The total score is the mean of all 12 items, with a resulting 1-5 range, in which higher scores indicate greater transdisciplinary collaboration orientation.
Outcome measures
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
Transdisciplinary Orientation Scale
Baseline (Month 0)
|
4.4 Score on a scale
Standard Error .08
|
4.4 Score on a scale
Standard Error .07
|
|
Transdisciplinary Orientation Scale
End of Treatment (Month 3)
|
4.2 Score on a scale
Standard Error .08
|
4.1 Score on a scale
Standard Error .11
|
|
Transdisciplinary Orientation Scale
6-Month Follow-Up (Month 9)
|
4.3 Score on a scale
Standard Error .08
|
4.4 Score on a scale
Standard Error .08
|
|
Transdisciplinary Orientation Scale
12-month Follow-Up (Month 15)
|
4.2 Score on a scale
Standard Error .09
|
4.4 Score on a scale
Standard Error .08
|
PRIMARY outcome
Timeframe: 36 Months (18-monts pre- and post-treatment, after excluding articles published within +/-3 months of the Innovation Lab)Objective number of collaborators from published articles on PubMed
Outcome measures
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
Collaboration Network Size
Pre-Treatment
|
27.6 Unique Collaborators
Standard Error 4.1
|
26.7 Unique Collaborators
Standard Error 3.7
|
|
Collaboration Network Size
Post-Treatment
|
34.6 Unique Collaborators
Standard Error 5.3
|
30.1 Unique Collaborators
Standard Error 4.8
|
SECONDARY outcome
Timeframe: 21 months (9 months pre-treatment [obtained at baseline and EOT]; 12 months post-treatment [obtained at 6- and 12-month follow-up])Self-Reported Number of Grants Submitted per Year. For the post-treatment period, the number of grants submitted at 6- and 12-M follow-up were summed. To make the pre-treatment period (which covered only 9 months) comparable to the post-treatment period, the number of grants at baseline and EOT were summed, divided by 9, and then multiplied by 12. Participants who did not report the number of grants submitted were coded as zero for the ITT analysis.
Outcome measures
| Measure |
Innovation Lab Group
n=47 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
n=47 Participants
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
Self-Reported Number of Grants Submitted Per Year
Post-Treatment
|
2.6 Grants per year
Standard Error .4
|
1.6 Grants per year
Standard Error .3
|
|
Self-Reported Number of Grants Submitted Per Year
Pre-Treatment
|
2.7 Grants per year
Standard Error .4
|
2.8 Grants per year
Standard Error .4
|
SECONDARY outcome
Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])Population: Differing number of participants responded at different assessment points.
The Innovation Lab group was asked to rate the degree to which "The Lab met the goal of forming new transdisciplinary collaborations", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.
Outcome measures
| Measure |
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
ILab Met Goal - New Collab
End of Treatment
|
4.3 Score on a scale
Standard Deviation 0.8
|
—
|
|
ILab Met Goal - New Collab
6-Month Follow-Up
|
3.7 Score on a scale
Standard Deviation 1.0
|
—
|
|
ILab Met Goal - New Collab
12-Month Follow-Up
|
2.9 Score on a scale
Standard Deviation 1.4
|
—
|
SECONDARY outcome
Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])Population: Differing number of participants responded at different assessment points.
The Innovation Lab group was asked to rate the degree to which "The Lab met the goal of developing novel grant proposals", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.
Outcome measures
| Measure |
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
ILab Met Goal - Novel Proposals
End of Treatment
|
3.7 Score on a scale
Standard Deviation 1.1
|
—
|
|
ILab Met Goal - Novel Proposals
6-Month Follow-Up
|
3.4 Score on a scale
Standard Deviation 1.1
|
—
|
|
ILab Met Goal - Novel Proposals
12-Month Follow-Up
|
2.6 Score on a scale
Standard Deviation 1.4
|
—
|
SECONDARY outcome
Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])Population: Differing number of participants responded at different assessment points.
The Innovation Lab group was asked to rate the degree to which "I would recommend an Innovation Lab to a colleague", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.
Outcome measures
| Measure |
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
ILab - Recommend
End of Treatment
|
4.4 Score on a scale
Standard Deviation 0.9
|
—
|
|
ILab - Recommend
6-Month Follow-Up
|
4.3 Score on a scale
Standard Deviation 0.9
|
—
|
|
ILab - Recommend
12-Month Follow-Up
|
3.8 Score on a scale
Standard Deviation 1.4
|
—
|
SECONDARY outcome
Timeframe: 12 months (End of Treatment [3 months post-baseline], 6-Month Follow-Up [9 months post-baseline], and 12-Month Follow-Up [15 months post-baseline])Population: Differing number of participants responded at different assessment points.
The Innovation Lab group was asked to rate the degree to which "My experience in the Innovation Lab will have a positive impact on my work at my home institution", answering on a 6-point scale (0 = "Strongly Disagree" to 5 = "Strongly Agree"), with higher scores indicating a beneficial effect of the Innovation Lab.
Outcome measures
| Measure |
Innovation Lab Group
n=36 Participants
Randomized to attend the Innovation Lab
Innovation Lab: An Innovation Lab is a facilitated 5-day residential event designed to create novel, transdisciplinary and potentially transformative research ideas and proposals to address a specific grand challenge. Participants, along with a director, organizers, subject matter guides, and KI facilitators communally explore the problem space, generate a broad range of ideas, and form transdisciplinary teams to pursue research projects.
|
Control Group
Randomized to NOT attend the Innovation Lab
|
|---|---|---|
|
ILab - Positive Impact
End of Treatment
|
4.4 Score on a scale
Standard Deviation 0.8
|
—
|
|
ILab - Positive Impact
6-Month Follow-Up
|
4.1 Score on a scale
Standard Deviation 0.9
|
—
|
|
ILab - Positive Impact
12-Month Follow-Up
|
3.7 Score on a scale
Standard Deviation 1.4
|
—
|
Adverse Events
Innovation Lab Group
Control Group
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place