Trial Outcomes & Findings for Ketamine Pilot Study (NCT NCT05379179)

Drug administration: A single dose of fentanyl 1mcg/kg IV, maximum 100 mcg, over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Fentanyl: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

Drug administration: A single dose of ketamine 0.3 mg/kg IV over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Ketamine: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=2 Participants

Drug administration: A single dose of fentanyl 1mcg/kg IV, maximum 100 mcg, over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Fentanyl: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=1 Participants

Drug administration: A single dose of ketamine 0.3 mg/kg IV over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Ketamine: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=3 Participants

Total of all reporting groups

n=2 Participants

Drug administration: A single dose of fentanyl 1mcg/kg IV, maximum 100 mcg, over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Fentanyl: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=1 Participants

Drug administration: A single dose of ketamine 0.3 mg/kg IV over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Ketamine: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=2 Participants

Drug administration: A single dose of fentanyl 1mcg/kg IV, maximum 100 mcg, over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Fentanyl: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.

n=1 Participants

Drug administration: A single dose of ketamine 0.3 mg/kg IV over 15 minutes. Time drug given will be documented Data obtained prior to med administration and then following medication administration at intervals of 15, 30, 60 and 120 minutes * Record vital signs (HR, B/P, resp rate, O2 sat) * Obtain and assess pain response scores 1. Pain Numerical Rating Score (NRS - 0-10) 2. Richmond Agitation Sedation Scale (RASS) 3. Side Effect Rating Scale for Dissociative Anesthesia (SERSDA) * Record any airway interventions required? If yes what? new supplemental O2/BVM/intubation, jaw thrust * Record any rescue meds, dose and time (Rescue medication - Fentanyl): * 1 mcg/kg IV fentanyl (0.5 mcg/kg if age \>55 yrs) * Defined as rescue if given \<30 min post study intervention for pain score \>5 or patient requesting additional medication. * Patient pain satisfaction score at discharge Ketamine: This study will compare patient-reported pain scores after receiving either ketamine or fentanyl for the treatment of acute pain due to a rattlesnake bite.