Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer
NCT05368428 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17
Last updated 2026-05-18
Summary
This phase II trial examines transcutaneous electrical nerve stimulation (TENS) in patients with stage I-III breast cancer with chemotherapy induced peripheral neuropathy. TENS is a procedure in which mild electric currents are applied to some areas of the skin to potentially improve neuropathy. This trial may help determine if TENS is feasible and effective for the treatment of peripheral neuropathy symptoms while on chemotherapy.
Conditions
- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage IA Breast Cancer AJCC v8
- Anatomic Stage IB Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage IIA Breast Cancer AJCC v8
- Anatomic Stage IIB Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IIIA Breast Cancer AJCC v8
- Anatomic Stage IIIB Breast Cancer AJCC v8
- Anatomic Stage IIIC Breast Cancer AJCC v8
- Chemotherapy-Induced Peripheral Neuropathy
- Early Stage Breast Carcinoma
- Prognostic Stage I Breast Cancer AJCC v8
- Prognostic Stage IA Breast Cancer AJCC v8
- Prognostic Stage IB Breast Cancer AJCC v8
- Prognostic Stage II Breast Cancer AJCC v8
- Prognostic Stage IIA Breast Cancer AJCC v8
- Prognostic Stage IIB Breast Cancer AJCC v8
- Prognostic Stage III Breast Cancer AJCC v8
- Prognostic Stage IIIA Breast Cancer AJCC v8
- Prognostic Stage IIIB Breast Cancer AJCC v8
- Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions
- OTHER
-
Transcutaneous Electrical Nerve Stimulation
Undergo TENS
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Emory University
lead OTHER
Principal Investigators
-
Manali Bhave, MD · Emory University Hospital/Winship Cancer Institute
Study Design
- Allocation
- NA
- Purpose
- SUPPORTIVE_CARE
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-10-19
- Primary Completion
- 2025-11-18
- Completion
- 2025-11-18
Countries
- United States
Study Locations
More Related Trials
-
Acupuncture to Reduce Chemotherapy-induced Peripheral Neuropathy Severity During Neoadjuvant or Adjuvant Weekly Paclitaxel Chemotherapy in Breast Cancer Patients
NCT02364726 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the Efficacy of Compression With Tight Surgical Gloves in Patients With Taxane-based Therapy
NCT06464536 ·Status: RECRUITING ·Phase: NA
-
Efficacy of Auricular Acupuncture Therapy in the Prevention of CIPN in Breast Cancer
NCT07092111 ·Status: RECRUITING ·Phase: NA
-
The CONTRoL Trial: Cryotherapy vs. cOmpression Neuropathy TRiaL
NCT03873272 ·Status: COMPLETED ·Phase: NA
-
Study of the Effects of Transcutaneous Vagus Nerve Stimulation on Cancer Patients
NCT04563013 ·Status: COMPLETED ·Phase: NA
-
A Pilot Study of Acupuncture for Chemotherapy-induced Peripheral Neuropathy in Breast Cancer Patients
NCT02129686 ·Status: COMPLETED ·Phase: NA
-
Cryoablation for Post Mastectomy Pain Syndrome
NCT03293940 ·Status: COMPLETED ·Phase: NA
-
Acupuncture Chemotherapy-Induced Peripheral Neuropathy (CIPN) IRG
NCT01815346 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel
NCT01050075 ·Status: TERMINATED ·Phase: NA
-
Topical Cryotherapy in Reducing Pain in Patients With Chemotherapy Induced Peripheral Neuropathy or Paclitaxel Induced Acute Pain Syndrome
NCT02640053 ·Status: COMPLETED ·Phase: NA
-
Effects of Transcutaneous Electrical Nerve Stimulation on Breast Surgery
NCT06973265 ·Status: COMPLETED ·Phase: NA
-
Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy
NCT03329131 ·Status: COMPLETED ·Phase: NA
-
Biomarkers of Neuropathic Pain in Women Treated for Breast Cancer
NCT02487524 ·Status: COMPLETED ·Phase: NA
-
Intraoperative Electron Beam Radiotherapy Boost in Treating Patients With Stage I-II Breast Cancer Undergoing Surgery With Reconstruction
NCT02927912 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Electroacupuncture Treatment of Peripheral Neuropathy After Taxane Chemotherapy for Breast Cancer
NCT06772935 ·Status: RECRUITING ·Phase: NA
-
Cryotherapy in Preventing Peripheral Neuropathy and Nail Toxicity in Patients With Breast Cancer Who Are Receiving Paclitaxel
NCT01243541 ·Status: TERMINATED ·Phase: NA
-
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681 ·Status: ACTIVE_NOT_RECRUITING
-
Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy
NCT05341141 ·Status: RECRUITING ·Phase: NA
-
Molecular-Genetic Mechanisms Associated With Chemotherapy-Induced Nerve Damage
NCT01293851 ·Status: TERMINATED
-
Precision Acupuncture in the Treatment of Peripheral Neuropathy After Taxanes Chemotherapy in Breast Cancer
NCT05099562 ·Status: UNKNOWN ·Phase: NA
-
Calcium and Magnesium Infusion for the Prevention of Taxane Induced Neuropathy
NCT01682499 ·Status: COMPLETED ·Phase: PHASE1
-
Skin Sensitivity Acupuncture and Kinesiotherapy on Breast Cancer Patients Subject to Chemotherapy With Taxans
NCT03373032 ·Status: COMPLETED ·Phase: NA
-
Effect of Neurotization on QoL and Sensory Restoration
NCT05206565 ·Status: WITHDRAWN ·Phase: NA
-
Prevention of Paclitaxel Neuropathy With Cryotherapy
NCT02230319 ·Status: UNKNOWN ·Phase: PHASE2
-
Acupuncture for Peripheral Neuropathy Induced by Paclitaxel in Early Stage Breast Cancer
NCT04461977 ·Status: COMPLETED ·Phase: NA