Appropriate Medication Use in Dutch Terminal Care

Summary

The AMUSE trial is a multicentre stepped-wedge cluster randomized controlled trial where medication optimization of patients with a life expectancy of less than three months is investigated by using CDSS-OPTIMED (a personalized medication advice to attending physicians of patients in the last phase of life) The investigators will include 250 patients, in 7 different study sites across the Netherlands. The primary outcome is an assessment of the quality of life of patients, two weeks after baseline assessment.

Conditions

• Palliative Care
• Terminal Care
• Medication Therapy Management
• Clinical Decision Support System (CDSS)
• Quality of Life

Interventions

DEVICE

CDSS-OPTIMED

The CDSS-OPTIMED is a software program that provides the physician with a personalized alert on whether to consider stopping or starting medication for a specific patient with a life expectancy of less than 3 months.

Sponsors & Collaborators

• Rijnstate Hospital

  collaborator OTHER

• Ikazia Hospital, Rotterdam

  collaborator OTHER

• Noordwest Ziekenhuisgroep

  collaborator OTHER

• Laurens Cadenza Zuid

  collaborator UNKNOWN

• Nijmegen University Academic Network Family Medicine

  collaborator NETWORK

• Gezondheidscentrum Krimpen

  collaborator UNKNOWN

• Prof.dr Carin (C.C.D.) van der Rijt

  lead OTHER

Principal Investigators

• Carin van der Rijt, Prof, MD · Erasmus Medical Center

• Eric Geijteman, MD, PhD · Erasmus Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-04-29

Primary Completion

2024-10-16

Completion

2025-02-20

Countries

• Netherlands

Study Locations