Evaluation of the Effect of SGLT-2 Inhibitors on Cardiac Remodeling in Post Myocardial Infarction Patients
NCT05335629 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54
Last updated 2024-02-01
Summary
A prospective, randomized, controlled study will be conducted at Clinical Cardioglogy department, Ain Shams University Hospitals, assessing the efficacy and tolerability of SGLT2 inhibitors (dapagliflozin) addition on the clinical outcome and cardiac remodeling markers of post myocardial infarction (MI) diabetic patients
Conditions
- Myocardial Infarction
- Diabetes Mellitus, Type 2
- Myocardial Remodeling, Ventricular
Interventions
- DRUG
-
Dapagliflozin 10Mg Tab
Dapagliflozin is a sodium-glucose cotransporter-2 inhibitor (SGLT2 inhibitor) which is a new class of hypoglycemic drugs, and they can block sodium-dependent glucose transporter-2 (SGLT2) located in the early proximal renal tubule to increase urinary glucose excretion and decrease the concentration of blood glucose
Sponsors & Collaborators
-
Ain Shams University
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2022-06-01
- Primary Completion
- 2023-10-01
- Completion
- 2023-10-01
Countries
- Egypt
Study Locations
More Related Trials
-
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
NCT03377335 ·Status: UNKNOWN ·Phase: PHASE4
-
A Clinical Study to Investigate the Effects of Dapagliflozin on Heart Work, Heart Nutrient Uptake, and Heart Muscle Efficiency in Type 2 Diabetes Patients
NCT03387683 ·Status: COMPLETED ·Phase: PHASE4
-
Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D)
NCT02973477 ·Status: COMPLETED ·Phase: PHASE4
-
Antiischemic Effects of Empagliflozin in Diabetic Patients With Refractory Angina
NCT04143321 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Genetic Polymorphism on the Clinical Outcome to SGLT2 Inhibitors in Heart Failure Patients
NCT06901609 ·Status: ACTIVE_NOT_RECRUITING
-
Safety and Effectiveness of SGLT-2 Inhibitors in Patients With Heart Failure and Diabetes
NCT02397421 ·Status: COMPLETED ·Phase: PHASE4
-
SGLT-2 Inhibition, Metabolomics and Cardiovascular/Kidney Disease
NCT03919656 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Kidney Function in Advanced Chronic Kidney Disease
NCT06982079 ·Status: RECRUITING ·Phase: PHASE3
-
Pharmacokinetic Evaluation of Empagliflozin
NCT03059056 ·Status: COMPLETED ·Phase: PHASE1
-
Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes
NCT05139914 ·Status: TERMINATED ·Phase: PHASE4
-
Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling
NCT05993897 ·Status: UNKNOWN ·Phase: NA
-
Dapagliflozin in Type 2 Diabetes Mellitus Patients (T2DM) With Nonalcoholic Fatty Liver Disease (NAFLD)
NCT05459701 ·Status: COMPLETED ·Phase: PHASE4
-
Cardio Renal Effects of SGLT2 Inhibitors Among Lupus Nephritis Patients
NCT05748925 ·Status: COMPLETED ·Phase: PHASE4
-
Investigation of Biomarker Response to SGLT2 Inhibition in Heart Failure
NCT06140251 ·Status: RECRUITING
-
Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease Patients
NCT06421870 ·Status: RECRUITING ·Phase: PHASE3
-
Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes
NCT06286878 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Impact of Dapagliflozin in Anemic Chronic Kidney Disease Patients
NCT06897605 ·Status: RECRUITING ·Phase: PHASE2
-
Effect of Dapagliflozin in Non-Diabetic Patients With Nephrotic Syndrome.
NCT05966818 ·Status: UNKNOWN ·Phase: PHASE4
-
Canagliflozin in Patients With Acute Decompansted Heart Failure
NCT05364190 ·Status: COMPLETED ·Phase: PHASE3
-
Empagliflozin on Cardiac-renal Injury in Patients With STEAMI Patients After Primary PCI
NCT03591991 ·Status: UNKNOWN ·Phase: NA
-
Dapagliflozin Therapy In Cardiac Surgery
NCT05621551 ·Status: COMPLETED ·Phase: PHASE4
-
Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure
NCT05885607 ·Status: ENROLLING_BY_INVITATION
-
Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients
NCT06585761 ·Status: RECRUITING
-
A Study to Evaluate the Effect of Dapagliflozin on Blood Glucose Level and Renal Safety in Patients With Type 2 Diabetes
NCT02413398 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension
NCT03006471 ·Status: COMPLETED ·Phase: PHASE4