Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer
NCT05296421 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16
Last updated 2026-05-04
Summary
This clinical trial investigates the nutrients pancreatic cancers depend on in which to survive and the processes these tumors use (metabolism) to obtain these nutrients. Giving U-13C-glucose during surgery may allow doctors to trace the metabolic activity of pancreatic cancer in research experiments done in the laboratory. These experiments may help researchers understand how cancer cells manage their nutrients when compared to normal pancreatic cells.
Conditions
Interventions
- PROCEDURE
-
Biopsy
Undergo biopsy
- PROCEDURE
-
Therapeutic Conventional Surgery
Undergo surgery
- OTHER
-
Uniformly-labeled [13C]glucose
Given IV
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Rutgers, The State University of New Jersey
lead OTHER
Principal Investigators
-
Howard S Hochster, MD · Rutgers Cancer Institute of New Jersey
Study Design
- Allocation
- NA
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-03-14
- Primary Completion
- 2027-03-01
- Completion
- 2027-07-01
Countries
- United States
Study Locations
More Related Trials
-
BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer
NCT02608229 ·Status: TERMINATED ·Phase: PHASE1
-
Investigate Role of Metabolic Imaging in Predicting Tumor Response/Outcome After Pancreatic CA Tx
NCT00767273 ·Status: COMPLETED ·Phase: NA
-
Feasibility of Obtaining and Characterizing Circulating Tumorigenic Cells in Patients With Pancreatic Adenocarcinoma
NCT01474564 ·Status: COMPLETED
-
Biomarkers in Predicting Response to Treatment in Patients Who Have Undergone Surgery for Pancreatic Cancer
NCT00897832 ·Status: COMPLETED
-
Safety Study of Cancer Stem Cell Vaccine to Treat Pancreatic Cancer
NCT02074046 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer
NCT03970252 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas
NCT00003049 ·Status: COMPLETED ·Phase: PHASE3
-
Metformin and Insulin to Pancreatic Cancer Related Diabetes (Type 3c)
NCT05306028 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Diet and Exercise After Pancreatic Cancer
NCT03187028 ·Status: COMPLETED ·Phase: NA
-
Combination Chemotherapy Followed by Chemotherapy and Radiation Therapy and/or Surgery in Treating Patients Who Have Pancreatic Cancer
NCT00003332 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer
NCT02048384 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Therapy for Patients With Untreated Metastatic Pancreatic Ductal Adenocarcinoma
NCT02754726 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of CP-4126 in Patients With Advanced Pancreatic Cancer
NCT00913198 ·Status: COMPLETED ·Phase: PHASE2
-
RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer
NCT01192763 ·Status: TERMINATED ·Phase: PHASE1
-
Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer
NCT07254091 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Detection of Circulating Tumor Cells for the Diagnostic of Pancreatic Adenocarcinoma.
NCT02072616 ·Status: TERMINATED ·Phase: NA
-
Targeting Pancreatic Cancer With Sodium Glucose Transporter 2 (SGLT2) Inhibition
NCT04542291 ·Status: COMPLETED ·Phase: PHASE1
-
Low Dose Vaccine Study for Surgically Resected Pancreatic Cancer
NCT00614601 ·Status: TERMINATED ·Phase: PHASE2
-
CAR-NK Cells (CL-NK-001) in Pancreatic Cancer
NCT06816823 ·Status: RECRUITING ·Phase: PHASE1
-
A Cohort Study on ctDNA MRD in Neoadjuvant Therapy for Pancreatic Cancer
NCT07080021 ·Status: RECRUITING
-
Panc CA Risk Model & Biomarker Testing In High-Risk Cohort
NCT05287347 ·Status: WITHDRAWN
-
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
NCT06122896 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Pancreatic Nutritional Program for Weight Loss in Overweight/Obese Patients With Stage I-III Breast Cancer
NCT02432950 ·Status: COMPLETED ·Phase: NA
-
A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma
NCT01660711 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of First-line L-glutamine With Gemcitabine and Nab-paclitaxel in Advanced Pancreatic Cancer
NCT04634539 ·Status: COMPLETED ·Phase: PHASE1