Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)
NCT05295459 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 182
Last updated 2026-02-19
Summary
Multicenter, phase III, randomized, blinded, controlled, parallel group.
Conditions
- Chronic Sinusitis
- Chronic Rhinosinusitis (Diagnosis)
Interventions
- DRUG
-
LYR-210
LYR-210 drug matrix (mometasone furoate)
- DRUG
-
Sham procedure control
Sham procedure control
- OTHER
-
Background therapy
Daily Saline Irrigation
Sponsors & Collaborators
-
Lyra Therapeutics
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-05-13
- Primary Completion
- 2025-04-02
- Completion
- 2025-04-02
- FDA Drug
- Yes
Countries
- United States
- Belgium
- Bulgaria
- Germany
- Hungary
- Poland
Study Locations
More Related Trials
-
Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis
NCT07290140 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Clinical Evaluation of Safety and Efficacy for the NEUROMARK System in Subjects With Chronic Rhinitis (PARAGON)
NCT05591989 ·Status: COMPLETED ·Phase: NA
-
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
NCT06338995 ·Status: RECRUITING ·Phase: PHASE3
-
Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR)
NCT00231062 ·Status: COMPLETED ·Phase: PHASE3
-
NEUROMARK Randomized Controlled Trial
NCT06128200 ·Status: COMPLETED ·Phase: NA
-
A Clinical Study to Evaluate the Safety and Effectiveness of Novabel Bioabsorbable Steroid-releasing Stent for the Chronic Sinusitis
NCT06020690 ·Status: RECRUITING ·Phase: NA
-
A Study of RhinAer Stylus for Treating Chronic Rhinitis
NCT06599736 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
RhinAer Procedure for Treatment of Chronic Rhinitis Study
NCT04533438 ·Status: COMPLETED ·Phase: NA
-
Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
NCT05400616 ·Status: RECRUITING ·Phase: NA
-
Effect of Low Level Laser Therapy in Patients With Chronic Rhinosinusitis.
NCT05861817 ·Status: COMPLETED ·Phase: NA
-
Microbiota Transfer for Chronic Rhinosinusitis
NCT05454072 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Treatment of Nasal Airway Obstruction Using the Aerin Medical Device
NCT02914236 ·Status: COMPLETED ·Phase: NA
-
NasoNeb Delivery of an Intranasal Steroid
NCT01270256 ·Status: COMPLETED ·Phase: PHASE4
-
Safety and Efficacy Study of the Neurent Medical NEUROMARK™ System in Subjects With Chronic Rhinitis (CLARITY)
NCT05324397 ·Status: COMPLETED ·Phase: NA
-
Erenumab for Idiosyncratic Facial Pain
NCT04249427 ·Status: COMPLETED ·Phase: PHASE4
-
Clinical Evaluation of the Ethmoid Sinus Spacer
NCT01054703 ·Status: TERMINATED ·Phase: NA
-
480 Biomedical Sinus Drug Depot
NCT02967731 ·Status: COMPLETED ·Phase: PHASE1
-
Effects of Endoscopic Sinus Surgery for Chronic Sinusitis on Asthma Control
NCT01066416 ·Status: TERMINATED ·Phase: NA
-
Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Extension Phase to Assess Safety
NCT01622569 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab
NCT03369574 ·Status: WITHDRAWN
-
SB705498 Proof of Concept Chamber Challenge in Subjects With Non Allergic Rhinitis
NCT01424514 ·Status: COMPLETED ·Phase: PHASE2
-
Laser Posterior Nasal Nerve Neurolysis
NCT07050992 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Assess Efficacy and Safety of a Nasal Spray in Adults With Dry or Irritated Nose
NCT06110117 ·Status: COMPLETED ·Phase: NA
-
Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis
NCT00335309 ·Status: COMPLETED ·Phase: NA
-
Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS).
NCT07184684 ·Status: RECRUITING ·Phase: PHASE2/PHASE3